Synthesis and hydrolysis studies of a peptide containing the reactive triad of serine proteases with an associated linker to a dye on a solid phase support

Synthesis and hydrolysis studies of a peptide containing the reactive triad of serine proteases with an associated linker to a dye on a solid phase support

The synthesis of a Tentagel-supported peptide incorporating the reactive triad of serine, histidine and aspartic acid, found within serine protease enzymes, is described.

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Veröffentlicht in:Organic & biomolecular chemistry 2003-05, Vol.1 (9), p.1486-1497
Hauptverfasser: Clough, John M, Jones, Ray V, McCann, Hannah, Morris, David J, Wills, Martin
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Aspartic Acid - chemistry
Aspartic Acid - metabolism
Coloring Agents - chemistry
Combinatorial Chemistry Techniques - methods
Esterases - chemistry
Histidine - chemistry
Histidine - metabolism
Hydrolysis
Microspheres
Molecular Sequence Data
Oligopeptides - chemical synthesis
Oligopeptides - chemistry
Serine - chemistry
Serine - metabolism
Serine Endopeptidases - chemistry
Serine Endopeptidases - metabolism
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Zusammenfassung:The synthesis of a Tentagel-supported peptide incorporating the reactive triad of serine, histidine and aspartic acid, found within serine protease enzymes, is described.
ISSN:1477-0520
DOI:10.1039/b302239k