Direct Lactonization of Alkenols via Osmium Tetroxide-Mediated Oxidative Cleavage

Direct Lactonization of Alkenols via Osmium Tetroxide-Mediated Oxidative Cleavage

A highly efficient, mild, and simple protocol is presented for the tandem OsO4-mediated oxidative cleavage/oxidative lactonization of alkenols to lactones. The protocol couples the OsO4-catalyzed oxidative cleavage of olefins with Oxone as the co-oxidant with the direct oxidation of aldehydes in alc...

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Veröffentlicht in:Organic letters 2003-08, Vol.5 (17), p.3089-3092
Hauptverfasser: Schomaker, Jennifer M, Travis, Benjamin R, Borhan, Babak
Format: Artikel
Sprache:eng
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Zusammenfassung:A highly efficient, mild, and simple protocol is presented for the tandem OsO4-mediated oxidative cleavage/oxidative lactonization of alkenols to lactones. The protocol couples the OsO4-catalyzed oxidative cleavage of olefins with Oxone as the co-oxidant with the direct oxidation of aldehydes in alcoholic solvents to their corresponding esters.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol035057f