Stimulation of the pituitary-adrenocortical axis and induction of tyrosine hydroxylase by nerve growth factor are not dependent on mouse submaxillary gland isorenin

A biologically active 2.5S NGF preparation free of renin-activity was prepared. Stimulation of the hypothalamo-pituitary-adrenocortical axis as well as induction of tyrosine hydroxylase in sympathetic ganglia are characteristic NGF effects and are not mediated by renin. These findings are confirmed...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Brain research 1981-07, Vol.217 (1), p.207-211
Hauptverfasser:	Otten, U., Goedert, M., Baumann, J.B., Girard, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenocorticotropic Hormone - blood Animals Drinking - drug effects Endopeptidases - physiology Enzyme Induction - drug effects Ganglia, Sympathetic - enzymology Injections, Intraventricular isorenin Male Mice nerve growth factor Nerve Growth Factors - physiology Pituitary-Adrenal System - physiology pituitary-adrenocortical axis Rats Submandibular Gland - physiology Tyrosine 3-Monooxygenase - biosynthesis tyrosine hydroxylase
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A biologically active 2.5S NGF preparation free of renin-activity was prepared. Stimulation of the hypothalamo-pituitary-adrenocortical axis as well as induction of tyrosine hydroxylase in sympathetic ganglia are characteristic NGF effects and are not mediated by renin. These findings are confirmed by observations showing that captopril, an angiotensin converting enzyme inhibitor, failed to block these responses.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(81)90202-X