Lactation modulates diurnal expression profiles of specific leptin receptor isoforms in the rat hypothalamus

We investigated the effects of lactation on diurnal changes in serum leptin and hypothalamic expression of the leptin receptor isoforms, Ob-Ra, -Rb, -Rc, -Re and -Rf in rats. In non-lactating rats, serum leptin concentration was increased at night while hypothalamic mRNA levels of Ob-Rb, -Rc and -Re...

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Veröffentlicht in:	Journal of endocrinology 2003-08, Vol.178 (2), p.225-232
Hauptverfasser:	Denis, RG, Bing, C, Naderali, EK, Vernon, RG, Williams, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Circadian Rhythm Female Fundamental and applied biological sciences. Psychology Hormones and neuropeptides. Regulation Hyperphagia - metabolism Hypothalamus - metabolism Hypothalamus. Hypophysis. Epiphysis. Urophysis Lactation - physiology Leptin - blood Protein Isoforms - genetics Protein Isoforms - metabolism Rats Rats, Wistar Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Receptors, Leptin Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Vertebrates: endocrinology
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Zusammenfassung:	We investigated the effects of lactation on diurnal changes in serum leptin and hypothalamic expression of the leptin receptor isoforms, Ob-Ra, -Rb, -Rc, -Re and -Rf in rats. In non-lactating rats, serum leptin concentration was increased at night while hypothalamic mRNA levels of Ob-Rb, -Rc and -Re decreased; by contrast, expression of Ob-Ra and Ob-Rf was unchanged at night. There were significant negative correlations between serum leptin and mRNA expression of Ob-Rb (P
ISSN:	0022-0795 1479-6805
DOI:	10.1677/joe.0.1780225