Use of pi-allyltricarbonyliron lactone complexes in the synthesis of taurospongin A: a potent inhibitor of DNA polymerase beta and HIV revers transcriptase

The total synthesis of taurospongin A by two new approaches has been achieved where pi-allyltricarbonyliron lactone complexes have been used to control highly stereoselective additions of the nucleophiles to a carbonyl unit located in the side chain of these complexes.

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Bibliographische Detailangaben
Veröffentlicht in:	Organic & biomolecular chemistry 2003-05, Vol.1 (10), p.1664-1675
Hauptverfasser:	Hollowood, Christopher J, Yamanoi, Shigeo, Ley, Steven V
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes - chemical synthesis Alkynes - pharmacology DNA Polymerase beta - antagonists & inhibitors Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacology Esters - chemical synthesis Esters - pharmacology HIV Reverse Transcriptase - antagonists & inhibitors Iron Compounds - chemistry Lactones - chemistry Reverse Transcriptase Inhibitors - chemical synthesis Reverse Transcriptase Inhibitors - pharmacology Stereoisomerism
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Beschreibung
Zusammenfassung:	The total synthesis of taurospongin A by two new approaches has been achieved where pi-allyltricarbonyliron lactone complexes have been used to control highly stereoselective additions of the nucleophiles to a carbonyl unit located in the side chain of these complexes.
ISSN:	1477-0520