Evaluation of antipyretic potential of Vernonia cinerea extract in rats

The methanol extract of the whole plant of Vernonia cinerea (MEVC) was evaluated for its antipyretic potential on normal body temperature and yeast‐induced pyrexia in rats. MEVC signiﬁcantly reduced the normal body temperature at doses of 250 and 500 mg/kg body weight p.o. MEVC also lowered the elev...

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Veröffentlicht in:	Phytotherapy research 2003-08, Vol.17 (7), p.804-806
Hauptverfasser:	Gupta, Malaya, Mazumder, U. K., Manikandan, L., Bhattacharya, S., Haldar, P. K., Roy, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Analgesics, Non-Narcotic - administration & dosage Analgesics, Non-Narcotic - pharmacology Analgesics, Non-Narcotic - therapeutic use Animals antipyretic activity Biological and medical sciences Body Temperature - drug effects Dose-Response Relationship, Drug Female Fever - prevention & control General pharmacology Male Medical sciences methanol extract MEVC Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Structures Rats Vernonia Vernonia cinerea Yeasts
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Zusammenfassung:	The methanol extract of the whole plant of Vernonia cinerea (MEVC) was evaluated for its antipyretic potential on normal body temperature and yeast‐induced pyrexia in rats. MEVC signiﬁcantly reduced the normal body temperature at doses of 250 and 500 mg/kg body weight p.o. MEVC also lowered the elevated body temperature in the case of yeast‐induced pyrexia in a dose dependent manner. The antipyretic effect of the extract at a dose of 500 mg/kg was identical to that of the standard drug paracetamol. Copyright © 2003 John Wiley & Sons, Ltd.
ISSN:	0951-418X 1099-1573
DOI:	10.1002/ptr.1230