MODIFICATION OF SPECTINOMYCIN: 1. SYNTHESIS OF 4-AMINOSPECTINOMYCINS

Preparation of 4-dihydro-4-deoxy-4(R)-aminospectinomycin (4a) and 4-dihydro-4-deoxy-4(S)-aminospectinomycin (4b) is described. 4a shows antibiotic activity comparable to spectinomycin, 4b is devoid of activity.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of antibiotics 1981, Vol.34(1), pp.16-21
Hauptverfasser:	MAIER, R., WOITUN, E., REUTER, A., REUTER, W., WETZEL, B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria - drug effects Chemical Phenomena Chemistry Spectinomycin - analogs & derivatives Spectinomycin - chemical synthesis Structure-Activity Relationship
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Preparation of 4-dihydro-4-deoxy-4(R)-aminospectinomycin (4a) and 4-dihydro-4-deoxy-4(S)-aminospectinomycin (4b) is described. 4a shows antibiotic activity comparable to spectinomycin, 4b is devoid of activity.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.34.16