A5 region modulation of the cardiorespiratory responses evoked from parabrachial cell bodies in the anaesthetised rat
We have examined the importance of the A5 region modulating cardiorespiratory responses evoked from the parabrachial complex (PB) in spontaneously breathing rats. Cardiorespiratory changes were analyzed in response to electrical stimulation and glutamate microinjections into the PB (10–20 nl, 1–2 nm...
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| Veröffentlicht in: | Brain research 2003-08, Vol.982 (1), p.108-118 |
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| creator | Dawid Milner, M.S. Lara, J.P. López de Miguel, M.P. López-González, M.V. Spyer, K.M. González-Barón, S. |
| description | We have examined the importance of the A5 region modulating cardiorespiratory responses evoked from the parabrachial complex (PB) in spontaneously breathing rats. Cardiorespiratory changes were analyzed in response to electrical stimulation and glutamate microinjections into the PB (10–20 nl, 1–2 nmol) before and after ipsilateral microinjection of muscimol (50 nl, 0.25 nmol) or lidocaine (50 nl, 0.5 nmol) within the A5 region. Stimulation of medial parabrachial and Kölliker–Fuse nuclei (mPB-KF) evoked a decrease in respiratory rate (
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| doi_str_mv | 10.1016/S0006-8993(03)03005-1 |
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P<0.001) with a rise in blood pressure (
P<0.001) and heart rate (
P<0.05). After muscimol or lidocaine microinjections within the A5 region, the pressor and heart rate responses to mPB-KF stimulation were reduced (
P<0.05, both cases). Muscimol within the A5 region altered the respiratory response to glutamate stimulation of mPB-KF, evoking an increase in respiratory rate (
P<0.05). Lidocaine abolished the respiratory response to mPB-KF stimulation. Stimulation of the lateral parabrachial nuclei (lPB) caused an increase in respiratory rate (
P<0.001) with a rise in blood pressure (
P<0.001) and heart rate (
P<0.05). Muscimol or lidocaine microinjections within A5 region decreased heart rate (
P<0.05) and pressor responses (
P<0.05) evoked from lPB. The increase of respiratory rate persisted unchanged. To confirm functional interactions between A5 and PB, extracellular recordings of putative A5 neurones were obtained during PB stimulation. Eighty-three A5 cells were recorded, 35 were activated from the mPB-KF (42%). The results indicate that neurones of the A5 region participate in the cardiorespiratory response evoked from the different regions of the PB complex. The possible mechanisms involved in these interactions are discussed.]]></description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/S0006-8993(03)03005-1</identifier><identifier>PMID: 12915245</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>A5 region ; Animals ; Biological and medical sciences ; Blood Pressure - drug effects ; Cardiovascular control ; Electric Stimulation ; Evoked Potentials ; Fundamental and applied biological sciences. Psychology ; Heart - physiology ; Heart Rate - drug effects ; Lidocaine - administration & dosage ; Microinjections ; Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration ; Muscimol - administration & dosage ; Neurons - physiology ; Parabrachial complex ; Pons - cytology ; Pons - physiology ; Rat ; Rats ; Rats, Sprague-Dawley ; Respiration - drug effects ; Respiratory control ; Respiratory Physiological Phenomena ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 2003-08, Vol.982 (1), p.108-118</ispartof><rights>2003 Elsevier B.V.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-4d0260666740387c9269714a37a315e63f1af5ef9531c8d1e62ff5aee3bacedf3</citedby><cites>FETCH-LOGICAL-c447t-4d0260666740387c9269714a37a315e63f1af5ef9531c8d1e62ff5aee3bacedf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0006-8993(03)03005-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27926,27927,45997</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15082228$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12915245$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dawid Milner, M.S.</creatorcontrib><creatorcontrib>Lara, J.P.</creatorcontrib><creatorcontrib>López de Miguel, M.P.</creatorcontrib><creatorcontrib>López-González, M.V.</creatorcontrib><creatorcontrib>Spyer, K.M.</creatorcontrib><creatorcontrib>González-Barón, S.</creatorcontrib><title>A5 region modulation of the cardiorespiratory responses evoked from parabrachial cell bodies in the anaesthetised rat</title><title>Brain research</title><addtitle>Brain Res</addtitle><description><![CDATA[We have examined the importance of the A5 region modulating cardiorespiratory responses evoked from the parabrachial complex (PB) in spontaneously breathing rats. Cardiorespiratory changes were analyzed in response to electrical stimulation and glutamate microinjections into the PB (10–20 nl, 1–2 nmol) before and after ipsilateral microinjection of muscimol (50 nl, 0.25 nmol) or lidocaine (50 nl, 0.5 nmol) within the A5 region. Stimulation of medial parabrachial and Kölliker–Fuse nuclei (mPB-KF) evoked a decrease in respiratory rate (
P<0.001) with a rise in blood pressure (
P<0.001) and heart rate (
P<0.05). After muscimol or lidocaine microinjections within the A5 region, the pressor and heart rate responses to mPB-KF stimulation were reduced (
P<0.05, both cases). Muscimol within the A5 region altered the respiratory response to glutamate stimulation of mPB-KF, evoking an increase in respiratory rate (
P<0.05). Lidocaine abolished the respiratory response to mPB-KF stimulation. Stimulation of the lateral parabrachial nuclei (lPB) caused an increase in respiratory rate (
P<0.001) with a rise in blood pressure (
P<0.001) and heart rate (
P<0.05). Muscimol or lidocaine microinjections within A5 region decreased heart rate (
P<0.05) and pressor responses (
P<0.05) evoked from lPB. The increase of respiratory rate persisted unchanged. To confirm functional interactions between A5 and PB, extracellular recordings of putative A5 neurones were obtained during PB stimulation. Eighty-three A5 cells were recorded, 35 were activated from the mPB-KF (42%). The results indicate that neurones of the A5 region participate in the cardiorespiratory response evoked from the different regions of the PB complex. The possible mechanisms involved in these interactions are discussed.]]></description><subject>A5 region</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiovascular control</subject><subject>Electric Stimulation</subject><subject>Evoked Potentials</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart - physiology</subject><subject>Heart Rate - drug effects</subject><subject>Lidocaine - administration & dosage</subject><subject>Microinjections</subject><subject>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</subject><subject>Muscimol - administration & dosage</subject><subject>Neurons - physiology</subject><subject>Parabrachial complex</subject><subject>Pons - cytology</subject><subject>Pons - physiology</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Respiration - drug effects</subject><subject>Respiratory control</subject><subject>Respiratory Physiological Phenomena</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1P3DAQhi3UqizQnwDypVV7SPFH7CQnhFApSEg9FM7WrD0uLkm82AkS_74Ou4IjliWPpWfe-XgJOebsB2dcn_5hjOmq7Tr5jcnvTDKmKr5HVrxtRKVFzT6Q1SuyTw5y_le-UnbsE9nnouNK1GpF5nNFE_4NcaRDdHMP0xJGT6d7pBaSCzFh3oQEU0zPdInjmDFTfIoP6KhPcaAbSLBOYO8D9NRi39N1dKFAYXzRgREwl2AKuaQUqSPy0UOf8fPuPSR3lz9vL66qm9-_ri_Obypb181U1Y4JzbTWTc1k29hO6K7hNcgGJFeopefgFfpOSW5bx1EL7xUgyjVYdF4ekq9b3U2Kj3PpwQwhLw3CiHHOppGqHK3fBXnb1awVvIBqC9oUc07ozSaFAdKz4cwsxpgXY8yydcOWW4wxS97JrsC8HtC9Ze2cKMCXHQDZQu8TjDbkN06V8kK0hTvbclj29hQwmWwDjmXckNBOxsXwTiv_AbLrq5o</recordid><startdate>20030822</startdate><enddate>20030822</enddate><creator>Dawid Milner, M.S.</creator><creator>Lara, J.P.</creator><creator>López de Miguel, M.P.</creator><creator>López-González, M.V.</creator><creator>Spyer, K.M.</creator><creator>González-Barón, S.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20030822</creationdate><title>A5 region modulation of the cardiorespiratory responses evoked from parabrachial cell bodies in the anaesthetised rat</title><author>Dawid Milner, M.S. ; Lara, J.P. ; López de Miguel, M.P. ; López-González, M.V. ; Spyer, K.M. ; González-Barón, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-4d0260666740387c9269714a37a315e63f1af5ef9531c8d1e62ff5aee3bacedf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>A5 region</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiovascular control</topic><topic>Electric Stimulation</topic><topic>Evoked Potentials</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart - physiology</topic><topic>Heart Rate - drug effects</topic><topic>Lidocaine - administration & dosage</topic><topic>Microinjections</topic><topic>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</topic><topic>Muscimol - administration & dosage</topic><topic>Neurons - physiology</topic><topic>Parabrachial complex</topic><topic>Pons - cytology</topic><topic>Pons - physiology</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Respiration - drug effects</topic><topic>Respiratory control</topic><topic>Respiratory Physiological Phenomena</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dawid Milner, M.S.</creatorcontrib><creatorcontrib>Lara, J.P.</creatorcontrib><creatorcontrib>López de Miguel, M.P.</creatorcontrib><creatorcontrib>López-González, M.V.</creatorcontrib><creatorcontrib>Spyer, K.M.</creatorcontrib><creatorcontrib>González-Barón, S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dawid Milner, M.S.</au><au>Lara, J.P.</au><au>López de Miguel, M.P.</au><au>López-González, M.V.</au><au>Spyer, K.M.</au><au>González-Barón, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A5 region modulation of the cardiorespiratory responses evoked from parabrachial cell bodies in the anaesthetised rat</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2003-08-22</date><risdate>2003</risdate><volume>982</volume><issue>1</issue><spage>108</spage><epage>118</epage><pages>108-118</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract><![CDATA[We have examined the importance of the A5 region modulating cardiorespiratory responses evoked from the parabrachial complex (PB) in spontaneously breathing rats. Cardiorespiratory changes were analyzed in response to electrical stimulation and glutamate microinjections into the PB (10–20 nl, 1–2 nmol) before and after ipsilateral microinjection of muscimol (50 nl, 0.25 nmol) or lidocaine (50 nl, 0.5 nmol) within the A5 region. Stimulation of medial parabrachial and Kölliker–Fuse nuclei (mPB-KF) evoked a decrease in respiratory rate (
P<0.001) with a rise in blood pressure (
P<0.001) and heart rate (
P<0.05). After muscimol or lidocaine microinjections within the A5 region, the pressor and heart rate responses to mPB-KF stimulation were reduced (
P<0.05, both cases). Muscimol within the A5 region altered the respiratory response to glutamate stimulation of mPB-KF, evoking an increase in respiratory rate (
P<0.05). Lidocaine abolished the respiratory response to mPB-KF stimulation. Stimulation of the lateral parabrachial nuclei (lPB) caused an increase in respiratory rate (
P<0.001) with a rise in blood pressure (
P<0.001) and heart rate (
P<0.05). Muscimol or lidocaine microinjections within A5 region decreased heart rate (
P<0.05) and pressor responses (
P<0.05) evoked from lPB. The increase of respiratory rate persisted unchanged. To confirm functional interactions between A5 and PB, extracellular recordings of putative A5 neurones were obtained during PB stimulation. Eighty-three A5 cells were recorded, 35 were activated from the mPB-KF (42%). The results indicate that neurones of the A5 region participate in the cardiorespiratory response evoked from the different regions of the PB complex. The possible mechanisms involved in these interactions are discussed.]]></abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>12915245</pmid><doi>10.1016/S0006-8993(03)03005-1</doi><tpages>11</tpages></addata></record> |
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| subjects | A5 region Animals Biological and medical sciences Blood Pressure - drug effects Cardiovascular control Electric Stimulation Evoked Potentials Fundamental and applied biological sciences. Psychology Heart - physiology Heart Rate - drug effects Lidocaine - administration & dosage Microinjections Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Muscimol - administration & dosage Neurons - physiology Parabrachial complex Pons - cytology Pons - physiology Rat Rats Rats, Sprague-Dawley Respiration - drug effects Respiratory control Respiratory Physiological Phenomena Vertebrates: nervous system and sense organs |
| title | A5 region modulation of the cardiorespiratory responses evoked from parabrachial cell bodies in the anaesthetised rat |
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