A5 region modulation of the cardiorespiratory responses evoked from parabrachial cell bodies in the anaesthetised rat

We have examined the importance of the A5 region modulating cardiorespiratory responses evoked from the parabrachial complex (PB) in spontaneously breathing rats. Cardiorespiratory changes were analyzed in response to electrical stimulation and glutamate microinjections into the PB (10–20 nl, 1–2 nm...

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Veröffentlicht in:	Brain research 2003-08, Vol.982 (1), p.108-118
Hauptverfasser:	Dawid Milner, M.S., Lara, J.P., López de Miguel, M.P., López-González, M.V., Spyer, K.M., González-Barón, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	A5 region Animals Biological and medical sciences Blood Pressure - drug effects Cardiovascular control Electric Stimulation Evoked Potentials Fundamental and applied biological sciences. Psychology Heart - physiology Heart Rate - drug effects Lidocaine - administration & dosage Microinjections Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Muscimol - administration & dosage Neurons - physiology Parabrachial complex Pons - cytology Pons - physiology Rat Rats Rats, Sprague-Dawley Respiration - drug effects Respiratory control Respiratory Physiological Phenomena Vertebrates: nervous system and sense organs
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Zusammenfassung:	We have examined the importance of the A5 region modulating cardiorespiratory responses evoked from the parabrachial complex (PB) in spontaneously breathing rats. Cardiorespiratory changes were analyzed in response to electrical stimulation and glutamate microinjections into the PB (10–20 nl, 1–2 nmol) before and after ipsilateral microinjection of muscimol (50 nl, 0.25 nmol) or lidocaine (50 nl, 0.5 nmol) within the A5 region. Stimulation of medial parabrachial and Kölliker–Fuse nuclei (mPB-KF) evoked a decrease in respiratory rate ( P
ISSN:	0006-8993 1872-6240
DOI:	10.1016/S0006-8993(03)03005-1