Xenotransplantation of stem/progenitor cells from human fetal brain to adult rats with spinal trauma

In vitro grown neural stem cells from human fetal brain were transplanted to adult rats with spinal trauma. The spinal cord was examined morphologically using histological and immunohistochemical methods on days 5, 15, 30, and 110. Human neural stem/progenitor cells were viable, migrated, and differ...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2003-04, Vol.135 (4), p.397-400
Hauptverfasser:	Stepanov, G A, Karpenko, D O, Aleksandrova, M A, Podgornyi, O V, Poltavtseva, R A, Pevishchin, A V, Marey, M V, Sukhikh, G T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bisbenzimidazole - metabolism Cell Differentiation - physiology Cell Movement Cell Survival Female Fetal Tissue Transplantation Fluorescent Dyes - metabolism Humans Intermediate Filament Proteins - metabolism Nerve Tissue Proteins - metabolism Nestin Neuroglia - cytology Neuroglia - metabolism Neurons - cytology Neurons - metabolism Rats Rats, Wistar Spinal Cord - cytology Spinal Cord - pathology Spinal Cord Injuries - pathology Spinal Cord Injuries - therapy Stem Cell Transplantation Stem Cells - physiology Transplantation, Heterologous
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Beschreibung
Zusammenfassung:	In vitro grown neural stem cells from human fetal brain were transplanted to adult rats with spinal trauma. The spinal cord was examined morphologically using histological and immunohistochemical methods on days 5, 15, 30, and 110. Human neural stem/progenitor cells were viable, migrated, and differentiated into neurons and glia in the traumatized spinal cord in adult rats.
ISSN:	0007-4888 1573-8221
DOI:	10.1023/A:1024633403155