Freeze fracture studies of muscle plasma membrane in human muscular dystrophy

Freeze fracture studies of muscle plasma membrane in human muscular dystrophy

Freeze fracture analysis of intramembranous particle density in skeletal muscle plasma dystrophy from 7 patients with Duchenne muscular dystrophy (DMD), 5 patients with facioscapulohumeral muscular dystrophy (FSH) and 5 patients with myotonic dystrophy (MyD) were carried out. Marked depletion of int...

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Veröffentlicht in:Acta neuropathologica 1981-01, Vol.54 (3), p.189-197
Hauptverfasser: Schotland, D L, Bonilla, E, Wakayama, Y
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Biopsy
Cell Membrane - ultrastructure
Child
Child, Preschool
Freeze Fracturing
freeze-fracture
Humans
Male
man
Microscopy, Electron, Scanning
Muscles - pathology
Muscles - ultrastructure
Muscular Dystrophies - pathology
muscular dystrophy
Myotonic Dystrophy - pathology
plasma membranes
skeletal muscle
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Zusammenfassung:Freeze fracture analysis of intramembranous particle density in skeletal muscle plasma dystrophy from 7 patients with Duchenne muscular dystrophy (DMD), 5 patients with facioscapulohumeral muscular dystrophy (FSH) and 5 patients with myotonic dystrophy (MyD) were carried out. Marked depletion of intramembranous particles including orthogonal arrays was noted in DMD while only orthogonal arrays were significantly decreased in FSH. No abnormalities were noted in MyD.
ISSN:0001-6322
1432-0533
DOI:10.1007/BF00687741