Mammalian metabolism of phencyclidine
In dogs, the major metabolite of phencyclidine was found to be 5-(N-(1'-phenylcyclohexyl)amino)pentanoic acid (1). The gamma -aminobutyric acid like metabolite was also pharmacologically evaluated to determine if the purported GABA-ergic mediated effects of phencyclidine on locomotor activity m...
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| Veröffentlicht in: | Journal of medicinal chemistry 1981-06, Vol.24 (6), p.666-669 |
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| container_end_page | 669 |
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| container_issue | 6 |
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| container_title | Journal of medicinal chemistry |
| container_volume | 24 |
| creator | Baker, John K Wohlford, James G Bradbury, Barton J Wirth, Philip W |
| description | In dogs, the major metabolite of phencyclidine was found to be 5-(N-(1'-phenylcyclohexyl)amino)pentanoic acid (1). The gamma -aminobutyric acid like metabolite was also pharmacologically evaluated to determine if the purported GABA-ergic mediated effects of phencyclidine on locomotor activity might be attributed to the metabolite. Preliminary pharmacological evaluation of 1 and its methyl ester indicates that the metabolite has little, if any, association with the effect of phencyclidine on locomotor activity. |
| doi_str_mv | 10.1021/jm00138a004 |
| format | Article |
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The gamma -aminobutyric acid like metabolite was also pharmacologically evaluated to determine if the purported GABA-ergic mediated effects of phencyclidine on locomotor activity might be attributed to the metabolite. Preliminary pharmacological evaluation of 1 and its methyl ester indicates that the metabolite has little, if any, association with the effect of phencyclidine on locomotor activity.</description><identifier>ISSN: 0022-2623</identifier><identifier>EISSN: 1520-4804</identifier><identifier>DOI: 10.1021/jm00138a004</identifier><identifier>PMID: 7252975</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Animals ; Dogs ; gamma-Aminobutyric Acid - pharmacology ; Male ; Mice ; Motor Activity - drug effects ; Phencyclidine - analogs & derivatives ; Phencyclidine - metabolism ; Phencyclidine - pharmacology</subject><ispartof>Journal of medicinal chemistry, 1981-06, Vol.24 (6), p.666-669</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a385t-8ae3977047184cead6f1674042f25d7004f7e4720522d2215fe9f9cfabf11fa43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jm00138a004$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jm00138a004$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2751,27055,27903,27904,56717,56767</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7252975$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baker, John K</creatorcontrib><creatorcontrib>Wohlford, James G</creatorcontrib><creatorcontrib>Bradbury, Barton J</creatorcontrib><creatorcontrib>Wirth, Philip W</creatorcontrib><title>Mammalian metabolism of phencyclidine</title><title>Journal of medicinal chemistry</title><addtitle>J. Med. Chem</addtitle><description>In dogs, the major metabolite of phencyclidine was found to be 5-(N-(1'-phenylcyclohexyl)amino)pentanoic acid (1). The gamma -aminobutyric acid like metabolite was also pharmacologically evaluated to determine if the purported GABA-ergic mediated effects of phencyclidine on locomotor activity might be attributed to the metabolite. Preliminary pharmacological evaluation of 1 and its methyl ester indicates that the metabolite has little, if any, association with the effect of phencyclidine on locomotor activity.</description><subject>Animals</subject><subject>Dogs</subject><subject>gamma-Aminobutyric Acid - pharmacology</subject><subject>Male</subject><subject>Mice</subject><subject>Motor Activity - drug effects</subject><subject>Phencyclidine - analogs & derivatives</subject><subject>Phencyclidine - metabolism</subject><subject>Phencyclidine - pharmacology</subject><issn>0022-2623</issn><issn>1520-4804</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLw0AUhQdRaq2uXAvdqAuJ3ntnJpMspfikRcW6cTNMkxlMzaNmErD_3mhLcSG4uovzcc7lY-wQ4RyB8GJeACCPDIDYYn2UBIGIQGyzPgBRQCHxXbbn_RwAOBLvsZ4iSbGSfXY8MUVh8syUw8I2ZlblmS-GlRsu3myZLJM8S7PS7rMdZ3JvD9Z3wF6ur6aj22D8cHM3uhwHhkeyCSJjeawUCIWRSKxJQ4ehEiDIkUxV959TVigCSZQSoXQ2dnHizMwhOiP4gJ2sehd19dFa3-gi84nNc1PaqvVacSkERvQviJLHIvwBz1ZgUlfe19bpRZ0Vpl5qBP1tT_-y19FH69p2Vth0w651dXmwyjPf2M9NbOp3HSqupJ4-PmukyVP0eo867vjTFW8Sr-dVW5edvT-XvwBWSIMm</recordid><startdate>198106</startdate><enddate>198106</enddate><creator>Baker, John K</creator><creator>Wohlford, James G</creator><creator>Bradbury, Barton J</creator><creator>Wirth, Philip W</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>198106</creationdate><title>Mammalian metabolism of phencyclidine</title><author>Baker, John K ; Wohlford, James G ; Bradbury, Barton J ; Wirth, Philip W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a385t-8ae3977047184cead6f1674042f25d7004f7e4720522d2215fe9f9cfabf11fa43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Animals</topic><topic>Dogs</topic><topic>gamma-Aminobutyric Acid - pharmacology</topic><topic>Male</topic><topic>Mice</topic><topic>Motor Activity - drug effects</topic><topic>Phencyclidine - analogs & derivatives</topic><topic>Phencyclidine - metabolism</topic><topic>Phencyclidine - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baker, John K</creatorcontrib><creatorcontrib>Wohlford, James G</creatorcontrib><creatorcontrib>Bradbury, Barton J</creatorcontrib><creatorcontrib>Wirth, Philip W</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baker, John K</au><au>Wohlford, James G</au><au>Bradbury, Barton J</au><au>Wirth, Philip W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mammalian metabolism of phencyclidine</atitle><jtitle>Journal of medicinal chemistry</jtitle><addtitle>J. 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| fulltext | fulltext |
| identifier | ISSN: 0022-2623 |
| ispartof | Journal of medicinal chemistry, 1981-06, Vol.24 (6), p.666-669 |
| issn | 0022-2623 1520-4804 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73544182 |
| source | MEDLINE; ACS Publications |
| subjects | Animals Dogs gamma-Aminobutyric Acid - pharmacology Male Mice Motor Activity - drug effects Phencyclidine - analogs & derivatives Phencyclidine - metabolism Phencyclidine - pharmacology |
| title | Mammalian metabolism of phencyclidine |
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