Mammalian metabolism of phencyclidine

Mammalian metabolism of phencyclidine

In dogs, the major metabolite of phencyclidine was found to be 5-(N-(1'-phenylcyclohexyl)amino)pentanoic acid (1). The gamma -aminobutyric acid like metabolite was also pharmacologically evaluated to determine if the purported GABA-ergic mediated effects of phencyclidine on locomotor activity m...

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Veröffentlicht in:Journal of medicinal chemistry 1981-06, Vol.24 (6), p.666-669
Hauptverfasser: Baker, John K, Wohlford, James G, Bradbury, Barton J, Wirth, Philip W
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Dogs
gamma-Aminobutyric Acid - pharmacology
Male
Mice
Motor Activity - drug effects
Phencyclidine - analogs & derivatives
Phencyclidine - metabolism
Phencyclidine - pharmacology
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Zusammenfassung:In dogs, the major metabolite of phencyclidine was found to be 5-(N-(1'-phenylcyclohexyl)amino)pentanoic acid (1). The gamma -aminobutyric acid like metabolite was also pharmacologically evaluated to determine if the purported GABA-ergic mediated effects of phencyclidine on locomotor activity might be attributed to the metabolite. Preliminary pharmacological evaluation of 1 and its methyl ester indicates that the metabolite has little, if any, association with the effect of phencyclidine on locomotor activity.
ISSN:0022-2623
1520-4804
DOI:10.1021/jm00138a004