Carboxymethylcellulose: Effect of Degree of Polymerization and Substitution on Tablet Disintegration and Dissolution

Highly polymerized grades of carboxymethylcellulose sodium serve effectively as disintegrating agents for tablets. The preferred disintegrants have a high degree of polymerization with a small number of carboxymethyl groups. Grades with a low degree of polymerization are poor disintegrating agents i...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1981-06, Vol.70 (6), p.611-613
Hauptverfasser:	Shah, N.H., Lazarus, J.H., Sheth, P.R., Jarowski, C.I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Binders-carboxymethylcellulose Binders—carboxymethylcellulose, effect of polymerization and substitution on tablet disintegration and dissolution Carboxymethylcellulose Sodium Carboxymethylcellulose-effect of polymerization and substitution on tablet disintegration and dissolution Chemistry, Pharmaceutical Disintegrants-carboxymethylcellulose Disintegrants—carboxymethylcellulose, effect of polymerization and substitution on tablet disintegration and dissolution Disintegration-tablets Disintegration—tablets, effect of carboxymethylcellulose polymerization and substitution Dissolution-tablets Dissolution—tablets, effect of carboxymethylcellulose polymerization and substitution effect of carboxymethylcellulose polymerization and substitution effect of polymerization and substitution on tablet disintegration and dissolution Methylcellulose - analogs & derivatives Polymers - chemical synthesis Solubility Sulfamethoxazole - administration & dosage Tablets Time Factors Viscosity
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Beschreibung
Zusammenfassung:	Highly polymerized grades of carboxymethylcellulose sodium serve effectively as disintegrating agents for tablets. The preferred disintegrants have a high degree of polymerization with a small number of carboxymethyl groups. Grades with a low degree of polymerization are poor disintegrating agents irrespective of their degree of substitution. The dissolution rates of sulfamethoxazole tablets correlated with the disintegration times.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600700609