Anti-angiogenic, antioxidant and xanthine oxidase inhibition activities of the mushroom Phellinus linteus

Fruiting bodies of Phellinus linteus were extracted with 70% ethanol at room temperature. The Phellinus linteus extract (PL) showed strong anti-angiogenic activity, which was detected using the chick embryo chorioallantoic membrane (CAM) assay. The in vitro antioxidant activities of PL were evaluate...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of ethnopharmacology 2003-09, Vol.88 (1), p.113-116
Hauptverfasser:	Song, Yun Seon, Kim, Sun-Hyoung, Sa, Jae-Hoon, Jin, Changbae, Lim, Chang-Jin, Park, Eun-Hee
Format:	Artikel
Sprache:	eng
Schlagworte:	Agaricales - chemistry Agaricales - metabolism Angiogenesis Inhibitors - metabolism Angiogenesis Inhibitors - pharmacology Animals Anti-angiogenic activity Antioxidant activity Antioxidants - metabolism Antioxidants - pharmacology Ascorbic Acid - metabolism Ascorbic Acid - pharmacology Biological and medical sciences Biphenyl Compounds - metabolism Brain - drug effects Brain - metabolism Chick Embryo Folk medicine Free Radical Scavengers - metabolism Free Radical Scavengers - pharmacology General pharmacology Hydrazines - metabolism Korea Lipid Peroxidation - drug effects Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phellinus linteus Picrates Rats Rats, Sprague-Dawley Xanthine Oxidase - antagonists & inhibitors Xanthine Oxidase - metabolism Xanthine Oxidase - pharmacology Xanthine oxidase inhibition
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Fruiting bodies of Phellinus linteus were extracted with 70% ethanol at room temperature. The Phellinus linteus extract (PL) showed strong anti-angiogenic activity, which was detected using the chick embryo chorioallantoic membrane (CAM) assay. The in vitro antioxidant activities of PL were evaluated using two different bioassays. PL was comparable to Vitamin C in scavenging the stable free radical 1,1-diphenyl-2-picrylhyrazyl (DPPH). It also inhibited lipid peroxidation (LPO) in a concentration-dependent manner. These results suggest that antioxidant and anti-angiogenic activities of Phellinus linteus would be partly responsible for its anti-tumor effect.
ISSN:	0378-8741 1872-7573
DOI:	10.1016/S0378-8741(03)00178-8