Neuroprotection and the role of neuroglobin
Another tissue haemoglobin, neuroglobin, was discovered in the vertebrate brain.7 Neuroglobin is a small (151 aminoacids) monomeric cytoplasmic haemoprotein that is expressed in human, mouse, rat, pufferfish, and zebrafish brain.7-10 Although mouse and human neuroglobin are 94% identical, neuroglobi...
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| Veröffentlicht in: | The Lancet (British edition) 2003-08, Vol.362 (9381), p.342-343 |
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| description | Another tissue haemoglobin, neuroglobin, was discovered in the vertebrate brain.7 Neuroglobin is a small (151 aminoacids) monomeric cytoplasmic haemoprotein that is expressed in human, mouse, rat, pufferfish, and zebrafish brain.7-10 Although mouse and human neuroglobin are 94% identical, neuroglobin is dissimilar to myoglobin ( |
| doi_str_mv | 10.1016/S0140-6736(03)14055-X |
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Neuroglobin transcript and protein are induced in cultured primary cortical neurons during the acute phases of a hypoxic challenge.11 Furthermore, forced overexpression of neuroglobin in a neuronal cell line resulted in increased cellular viability in response to a hypoxic challenge. By contrast, Mammen et al12 observed no global changes in neuroglobin expression in the brains of mice exposed to chronic hypoxic conditions. These results suggest that neuroglobin might function during the acute phases of a hypoxic (ischaemic) insult to preserve neuronal viability, and may have implications for the treatment of cerebrovascular accidents.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(03)14055-X</identifier><identifier>PMID: 12907003</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Brain ; Danio rerio ; Disease Models, Animal ; Globins - metabolism ; Globins - physiology ; Globins - therapeutic use ; Hemoglobin ; Humans ; Hypoxia ; Mice ; Mice, Knockout ; Mollusca ; Myoglobins ; Nerve Tissue Proteins - metabolism ; Nerve Tissue Proteins - physiology ; Nerve Tissue Proteins - therapeutic use ; Nervous system ; Neuroglobin ; Neurons - drug effects ; Neurons - metabolism ; Neurons - physiology ; Neuroprotection ; Neuroprotective Agents - pharmacology ; Neuroprotective Agents - therapeutic use ; Nitric oxide ; Oxygen ; Rats ; Rodents ; Stroke - drug therapy ; Stroke - physiopathology ; Stroke - prevention & control ; Veins & arteries</subject><ispartof>The Lancet (British edition), 2003-08, Vol.362 (9381), p.342-343</ispartof><rights>2003 Elsevier Ltd</rights><rights>Copyright Lancet Ltd. Aug 2, 2003</rights><rights>Copyright Elsevier Limited Aug 2, 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-23f8fcefba36894aa1ab17554551095ab8b596f830d45e9cb5fcb013f2b5340c3</citedby><cites>FETCH-LOGICAL-c416t-23f8fcefba36894aa1ab17554551095ab8b596f830d45e9cb5fcb013f2b5340c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/199079078?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12907003$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garry, Daniel J</creatorcontrib><creatorcontrib>Mammen, Pradeep PA</creatorcontrib><title>Neuroprotection and the role of neuroglobin</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>Another tissue haemoglobin, neuroglobin, was discovered in the vertebrate brain.7 Neuroglobin is a small (151 aminoacids) monomeric cytoplasmic haemoprotein that is expressed in human, mouse, rat, pufferfish, and zebrafish brain.7-10 Although mouse and human neuroglobin are 94% identical, neuroglobin is dissimilar to myoglobin (<21% identity).7 Neuroglobin is expressed in focal regions of the brain at low concentrations (less than 0[middot]01% of the protein content) and reversibly binds oxygen, but less avidly than myoglobin.7 The discovery of neuroglobin suggests that the brain, like the heart, contains a tissue haemoglobin that functions in the delivery and storage of oxygen and prevents hypoxic insults. Neuroglobin transcript and protein are induced in cultured primary cortical neurons during the acute phases of a hypoxic challenge.11 Furthermore, forced overexpression of neuroglobin in a neuronal cell line resulted in increased cellular viability in response to a hypoxic challenge. By contrast, Mammen et al12 observed no global changes in neuroglobin expression in the brains of mice exposed to chronic hypoxic conditions. These results suggest that neuroglobin might function during the acute phases of a hypoxic (ischaemic) insult to preserve neuronal viability, and may have implications for the treatment of cerebrovascular accidents.</description><subject>Animals</subject><subject>Brain</subject><subject>Danio rerio</subject><subject>Disease Models, Animal</subject><subject>Globins - metabolism</subject><subject>Globins - physiology</subject><subject>Globins - therapeutic use</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Mollusca</subject><subject>Myoglobins</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Nerve Tissue Proteins - physiology</subject><subject>Nerve Tissue Proteins - therapeutic use</subject><subject>Nervous system</subject><subject>Neuroglobin</subject><subject>Neurons - drug effects</subject><subject>Neurons - metabolism</subject><subject>Neurons - physiology</subject><subject>Neuroprotection</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Neuroprotective Agents - therapeutic use</subject><subject>Nitric oxide</subject><subject>Oxygen</subject><subject>Rats</subject><subject>Rodents</subject><subject>Stroke - drug therapy</subject><subject>Stroke - physiopathology</subject><subject>Stroke - prevention & control</subject><subject>Veins & 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PA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuroprotection and the role of neuroglobin</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>2003-08-02</date><risdate>2003</risdate><volume>362</volume><issue>9381</issue><spage>342</spage><epage>343</epage><pages>342-343</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>Another tissue haemoglobin, neuroglobin, was discovered in the vertebrate brain.7 Neuroglobin is a small (151 aminoacids) monomeric cytoplasmic haemoprotein that is expressed in human, mouse, rat, pufferfish, and zebrafish brain.7-10 Although mouse and human neuroglobin are 94% identical, neuroglobin is dissimilar to myoglobin (<21% identity).7 Neuroglobin is expressed in focal regions of the brain at low concentrations (less than 0[middot]01% of the protein content) and reversibly binds oxygen, but less avidly than myoglobin.7 The discovery of neuroglobin suggests that the brain, like the heart, contains a tissue haemoglobin that functions in the delivery and storage of oxygen and prevents hypoxic insults. Neuroglobin transcript and protein are induced in cultured primary cortical neurons during the acute phases of a hypoxic challenge.11 Furthermore, forced overexpression of neuroglobin in a neuronal cell line resulted in increased cellular viability in response to a hypoxic challenge. By contrast, Mammen et al12 observed no global changes in neuroglobin expression in the brains of mice exposed to chronic hypoxic conditions. These results suggest that neuroglobin might function during the acute phases of a hypoxic (ischaemic) insult to preserve neuronal viability, and may have implications for the treatment of cerebrovascular accidents.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>12907003</pmid><doi>10.1016/S0140-6736(03)14055-X</doi><tpages>2</tpages></addata></record> |
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| subjects | Animals Brain Danio rerio Disease Models, Animal Globins - metabolism Globins - physiology Globins - therapeutic use Hemoglobin Humans Hypoxia Mice Mice, Knockout Mollusca Myoglobins Nerve Tissue Proteins - metabolism Nerve Tissue Proteins - physiology Nerve Tissue Proteins - therapeutic use Nervous system Neuroglobin Neurons - drug effects Neurons - metabolism Neurons - physiology Neuroprotection Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Nitric oxide Oxygen Rats Rodents Stroke - drug therapy Stroke - physiopathology Stroke - prevention & control Veins & arteries |
| title | Neuroprotection and the role of neuroglobin |
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