Neuroprotection and the role of neuroglobin

Another tissue haemoglobin, neuroglobin, was discovered in the vertebrate brain.7 Neuroglobin is a small (151 aminoacids) monomeric cytoplasmic haemoprotein that is expressed in human, mouse, rat, pufferfish, and zebrafish brain.7-10 Although mouse and human neuroglobin are 94% identical, neuroglobi...

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Veröffentlicht in:	The Lancet (British edition) 2003-08, Vol.362 (9381), p.342-343
Hauptverfasser:	Garry, Daniel J, Mammen, Pradeep PA
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Danio rerio Disease Models, Animal Globins - metabolism Globins - physiology Globins - therapeutic use Hemoglobin Humans Hypoxia Mice Mice, Knockout Mollusca Myoglobins Nerve Tissue Proteins - metabolism Nerve Tissue Proteins - physiology Nerve Tissue Proteins - therapeutic use Nervous system Neuroglobin Neurons - drug effects Neurons - metabolism Neurons - physiology Neuroprotection Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Nitric oxide Oxygen Rats Rodents Stroke - drug therapy Stroke - physiopathology Stroke - prevention & control Veins & arteries
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Beschreibung
Zusammenfassung:	Another tissue haemoglobin, neuroglobin, was discovered in the vertebrate brain.7 Neuroglobin is a small (151 aminoacids) monomeric cytoplasmic haemoprotein that is expressed in human, mouse, rat, pufferfish, and zebrafish brain.7-10 Although mouse and human neuroglobin are 94% identical, neuroglobin is dissimilar to myoglobin (
ISSN:	0140-6736 1474-547X
DOI:	10.1016/S0140-6736(03)14055-X