Effects of leptin gene expression in mice in vivo by electroporation and hydrodynamics-based gene delivery

In vivo electroporation and hydrodynamics-based gene delivery were utilized to test the effect of leptin gene transfer on food intake, and body and fat weights of mice. Gene transfer of pVRmob by electroporation caused a significant reduction in body weight compared with the control counterpart ( p

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Bibliographische Detailangaben
Veröffentlicht in:	Biochemical and biophysical research communications 2003-08, Vol.307 (3), p.440-445
Hauptverfasser:	Xiang, Lan, Murai, Atsushi, Sugahara, Kunio, Yasui, Akihiro, Muramatsu, Tatsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - anatomy & histology Animals Body Weight Eating Electroporation Food intake Gene Expression Green Fluorescent Proteins Hydrodynamics-based gene delivery In vivo electroporation Leptin - biosynthesis Leptin - blood Leptin - genetics Leptin expression vector Luminescent Proteins - biosynthesis Luminescent Proteins - genetics Male Mice Mice, Inbred ICR Muscle, Skeletal - chemistry RNA, Messenger - analysis Transfection - methods Water - chemistry
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Beschreibung
Zusammenfassung:	In vivo electroporation and hydrodynamics-based gene delivery were utilized to test the effect of leptin gene transfer on food intake, and body and fat weights of mice. Gene transfer of pVRmob by electroporation caused a significant reduction in body weight compared with the control counterpart ( p
ISSN:	0006-291X 1090-2104
DOI:	10.1016/S0006-291X(03)01172-0