Acute bullous purpura associated with hyperhomocysteinemia and antiphospholipid antibodies

We describe a female patient with an acute purpuric and bullous eruption mainly affecting the lower aspect of the legs. Skin biopsy specimens demonstrated microvascular occlusions with fibrin thrombi but no dermal inflammation. Intermediate hyperhomocysteinemia and transient antiphospholipid antibod...

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Veröffentlicht in:	Journal of the American Academy of Dermatology 2003-08, Vol.49 (2), p.161-163
Hauptverfasser:	Martin, Ludovic, Armingaud, Pierre, Georgescu, Voichita, Maı̂tre, Frédéric, Legac, Eric, Estève, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Aged Antibodies, Antiphospholipid - immunology Antiphospholipid Syndrome - complications Antiphospholipid Syndrome - diagnosis Antiphospholipid Syndrome - drug therapy Biological and medical sciences Biopsy, Needle Dermatology Female Humans Immunohistochemistry Medical sciences Prednisone - administration & dosage Prognosis Purpura - immunology Purpura - pathology Risk Assessment Severity of Illness Index Skin Diseases, Vesiculobullous - drug therapy Skin Diseases, Vesiculobullous - immunology Skin Diseases, Vesiculobullous - pathology Thrombophilia - complications Thrombophilia - diagnosis Thrombophilia - drug therapy Treatment Outcome Vascular disorders of the skin
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Beschreibung
Zusammenfassung:	We describe a female patient with an acute purpuric and bullous eruption mainly affecting the lower aspect of the legs. Skin biopsy specimens demonstrated microvascular occlusions with fibrin thrombi but no dermal inflammation. Intermediate hyperhomocysteinemia and transient antiphospholipid antibodies were evidenced as factors of thrombophilia. The responsibility of the latter in the onset of the cutaneous lesions is discussed.
ISSN:	0190-9622 1097-6787
DOI:	10.1067/mjd.2003.340