Role of MAP kinase in tumor progression and invasion

Role of MAP kinase in tumor progression and invasion

Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway is a frequent event in tumorigenesis. MAPKs have been implicated in cell migration, proteinase-induction, regulation of apoptosis, and angiogenesis, events that are essential for successful co...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cancer and metastasis reviews 2003-12, Vol.22 (4), p.395-403
Hauptverfasser: Reddy, Kaladhar B, Nabha, Sanaa M, Atanaskova, Natasha
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis
Cell Movement
Disease Progression
Humans
MAP Kinase Signaling System
Models, Biological
Neoplasm Invasiveness
Neoplasms - enzymology
Neoplasms - pathology
Neovascularization, Pathologic
Signal Transduction
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway is a frequent event in tumorigenesis. MAPKs have been implicated in cell migration, proteinase-induction, regulation of apoptosis, and angiogenesis, events that are essential for successful completion of metastasis. In this review, we discuss the potential role that MAPKs play in metastasis by regulating cell migration, proteinase-induction and apoptosis.
ISSN:0167-7659
1573-7233
DOI:10.1023/a:1023781114568