Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14

Familial Alzheimer's disease (FAD) has been shown to be genetically heterogeneous, with a very small proportion of early onset pedigrees being associated with mutations in the amyloid precursor protein ( APP ) gene on chromosome 21, and some late onset pedigrees showing associations with markers on chromosome 19. We now provide evidence for a major early onset FAD locus on the long arm of chromosome 14 near the markers D14S43 and D14S53 (multipoint lod score ẑ = 23.4) and suggest that the inheritance of FAD may be more complex than had initially been suspected.