Expression of 5-HT2B and 5-HT2C receptor genes is associated with proliferative regions of Xenopus developing brain and eye
Here we clone the Xenopus 5-HT2B receptor cDNA and describe its spatio-temporal mRNA expression within the developing larval brain and visual system. Expression of the 5-HT2B transcripts is compared to that of 5-HT2C as well as proliferation and neurogenic markers. In developing brain and retina, 5-...
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| Veröffentlicht in: | Brain research. Molecular brain research. 2003-07, Vol.115 (2), p.196-201 |
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| container_title | Brain research. Molecular brain research. |
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| creator | De Lucchini, Stefania Ori, Michela Nardini, Martina Marracci, Silvia Nardi, Irma |
| description | Here we clone the
Xenopus 5-HT2B receptor cDNA and describe its spatio-temporal mRNA expression within the developing larval brain and visual system. Expression of the 5-HT2B transcripts is compared to that of 5-HT2C as well as proliferation and neurogenic markers. In developing brain and retina, 5-HT2B and 2C mRNAs are mainly expressed in proliferative regions. We suggest that these receptors may play a role in the larval secondary neurogenesis by mediating mitogenic effects of serotonin. |
| doi_str_mv | 10.1016/S0169-328X(03)00173-6 |
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Xenopus 5-HT2B receptor cDNA and describe its spatio-temporal mRNA expression within the developing larval brain and visual system. Expression of the 5-HT2B transcripts is compared to that of 5-HT2C as well as proliferation and neurogenic markers. In developing brain and retina, 5-HT2B and 2C mRNAs are mainly expressed in proliferative regions. We suggest that these receptors may play a role in the larval secondary neurogenesis by mediating mitogenic effects of serotonin.</description><identifier>ISSN: 0169-328X</identifier><identifier>EISSN: 1872-6941</identifier><identifier>DOI: 10.1016/S0169-328X(03)00173-6</identifier><identifier>PMID: 12877990</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>5-HT2B receptor ; Animals ; Biological and medical sciences ; Brain - embryology ; Brain - metabolism ; Bromodeoxyuridine - pharmacokinetics ; Cloning, Molecular ; Cyclin D1 - genetics ; Cyclin D1 - metabolism ; Development. Senescence. Regeneration. Transplantation ; Embryo, Nonmammalian ; Eye - embryology ; Eye - metabolism ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation, Developmental ; Genetic Markers ; In Situ Hybridization ; Larva - genetics ; Larva - metabolism ; Membrane Proteins - genetics ; Membrane Proteins - metabolism ; Molecular Sequence Data ; Nervous system development ; Radiation-Sensitizing Agents - pharmacokinetics ; Receptor, Notch1 ; Receptor, Serotonin, 5-HT2A ; Receptor, Serotonin, 5-HT2B ; Receptors, Cell Surface ; Receptors, Serotonin - genetics ; Receptors, Serotonin - metabolism ; Retina ; Reverse Transcriptase Polymerase Chain Reaction - methods ; RNA, Messenger - biosynthesis ; Secondary neurogenesis ; Serotonin receptors ; Transcription Factors ; Vertebrates: nervous system and sense organs ; Xenopus ; Xenopus - genetics ; Xenopus Proteins - metabolism</subject><ispartof>Brain research. Molecular brain research., 2003-07, Vol.115 (2), p.196-201</ispartof><rights>2003 Elsevier B.V.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-dc52bdecd736417d9c6c1537fe79499c84dd299b91109916d1dd8ebc0fc4958a3</citedby><cites>FETCH-LOGICAL-c422t-dc52bdecd736417d9c6c1537fe79499c84dd299b91109916d1dd8ebc0fc4958a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15018036$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12877990$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Lucchini, Stefania</creatorcontrib><creatorcontrib>Ori, Michela</creatorcontrib><creatorcontrib>Nardini, Martina</creatorcontrib><creatorcontrib>Marracci, Silvia</creatorcontrib><creatorcontrib>Nardi, Irma</creatorcontrib><title>Expression of 5-HT2B and 5-HT2C receptor genes is associated with proliferative regions of Xenopus developing brain and eye</title><title>Brain research. Molecular brain research.</title><addtitle>Brain Res Mol Brain Res</addtitle><description>Here we clone the
Xenopus 5-HT2B receptor cDNA and describe its spatio-temporal mRNA expression within the developing larval brain and visual system. Expression of the 5-HT2B transcripts is compared to that of 5-HT2C as well as proliferation and neurogenic markers. In developing brain and retina, 5-HT2B and 2C mRNAs are mainly expressed in proliferative regions. We suggest that these receptors may play a role in the larval secondary neurogenesis by mediating mitogenic effects of serotonin.</description><subject>5-HT2B receptor</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - embryology</subject><subject>Brain - metabolism</subject><subject>Bromodeoxyuridine - pharmacokinetics</subject><subject>Cloning, Molecular</subject><subject>Cyclin D1 - genetics</subject><subject>Cyclin D1 - metabolism</subject><subject>Development. Senescence. Regeneration. Transplantation</subject><subject>Embryo, Nonmammalian</subject><subject>Eye - embryology</subject><subject>Eye - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genetic Markers</subject><subject>In Situ Hybridization</subject><subject>Larva - genetics</subject><subject>Larva - metabolism</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Proteins - metabolism</subject><subject>Molecular Sequence Data</subject><subject>Nervous system development</subject><subject>Radiation-Sensitizing Agents - pharmacokinetics</subject><subject>Receptor, Notch1</subject><subject>Receptor, Serotonin, 5-HT2A</subject><subject>Receptor, Serotonin, 5-HT2B</subject><subject>Receptors, Cell Surface</subject><subject>Receptors, Serotonin - genetics</subject><subject>Receptors, Serotonin - metabolism</subject><subject>Retina</subject><subject>Reverse Transcriptase Polymerase Chain Reaction - methods</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Secondary neurogenesis</subject><subject>Serotonin receptors</subject><subject>Transcription Factors</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Xenopus</subject><subject>Xenopus - genetics</subject><subject>Xenopus Proteins - metabolism</subject><issn>0169-328X</issn><issn>1872-6941</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAUhS1ERYfCTwB5A4JFwI8kjlcIRqWtVIkFRerOcuybwShjB9_MQMWfx_NQu-zG14vvnnt0DiGvOPvAGW8_fi-PrqTobt8x-Z4xrmTVPiEL3ilRtbrmT8niHjklzxF_sUJ1nD8jp1x0SmnNFuTf-d8pA2JIkaaBNtXljfhCbfSH75JmcDDNKdMVREAakFrE5IKdwdM_Yf5Jp5zGMEC2c9hC4VdFC3ditxDTtEHqYQtjmkJc0T7bEPfycAcvyMlgR4SXx3lGfnw9v1leVtffLq6Wn68rVwsxV941ovfgvJJtzZXXrnW8kWoApWutXVd7L7TuNedMa9567n0HvWODq3XTWXlG3h50i9PfG8DZrAM6GEcbIW3QKNmU-Jh4FORKaMFZV8DmALqcEDMMZsphbfOd4czs6jH7eswue8Ok2ddj2rL3-nhg06_BP2wd-yjAmyNg0dlxyDa6gA9cMdoxuRP6dOCg5LYNkA26ANGBD6Ww2fgUHrHyHwpbrLw</recordid><startdate>20030723</startdate><enddate>20030723</enddate><creator>De Lucchini, Stefania</creator><creator>Ori, Michela</creator><creator>Nardini, Martina</creator><creator>Marracci, Silvia</creator><creator>Nardi, Irma</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>L.G</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20030723</creationdate><title>Expression of 5-HT2B and 5-HT2C receptor genes is associated with proliferative regions of Xenopus developing brain and eye</title><author>De Lucchini, Stefania ; Ori, Michela ; Nardini, Martina ; Marracci, Silvia ; Nardi, Irma</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-dc52bdecd736417d9c6c1537fe79499c84dd299b91109916d1dd8ebc0fc4958a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>5-HT2B receptor</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - embryology</topic><topic>Brain - metabolism</topic><topic>Bromodeoxyuridine - pharmacokinetics</topic><topic>Cloning, Molecular</topic><topic>Cyclin D1 - genetics</topic><topic>Cyclin D1 - metabolism</topic><topic>Development. Senescence. Regeneration. Transplantation</topic><topic>Embryo, Nonmammalian</topic><topic>Eye - embryology</topic><topic>Eye - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Genetic Markers</topic><topic>In Situ Hybridization</topic><topic>Larva - genetics</topic><topic>Larva - metabolism</topic><topic>Membrane Proteins - genetics</topic><topic>Membrane Proteins - metabolism</topic><topic>Molecular Sequence Data</topic><topic>Nervous system development</topic><topic>Radiation-Sensitizing Agents - pharmacokinetics</topic><topic>Receptor, Notch1</topic><topic>Receptor, Serotonin, 5-HT2A</topic><topic>Receptor, Serotonin, 5-HT2B</topic><topic>Receptors, Cell Surface</topic><topic>Receptors, Serotonin - genetics</topic><topic>Receptors, Serotonin - metabolism</topic><topic>Retina</topic><topic>Reverse Transcriptase Polymerase Chain Reaction - methods</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Secondary neurogenesis</topic><topic>Serotonin receptors</topic><topic>Transcription Factors</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Xenopus</topic><topic>Xenopus - genetics</topic><topic>Xenopus Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Lucchini, Stefania</creatorcontrib><creatorcontrib>Ori, Michela</creatorcontrib><creatorcontrib>Nardini, Martina</creatorcontrib><creatorcontrib>Marracci, Silvia</creatorcontrib><creatorcontrib>Nardi, Irma</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research. Molecular brain research.</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Lucchini, Stefania</au><au>Ori, Michela</au><au>Nardini, Martina</au><au>Marracci, Silvia</au><au>Nardi, Irma</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of 5-HT2B and 5-HT2C receptor genes is associated with proliferative regions of Xenopus developing brain and eye</atitle><jtitle>Brain research. Molecular brain research.</jtitle><addtitle>Brain Res Mol Brain Res</addtitle><date>2003-07-23</date><risdate>2003</risdate><volume>115</volume><issue>2</issue><spage>196</spage><epage>201</epage><pages>196-201</pages><issn>0169-328X</issn><eissn>1872-6941</eissn><abstract>Here we clone the
Xenopus 5-HT2B receptor cDNA and describe its spatio-temporal mRNA expression within the developing larval brain and visual system. Expression of the 5-HT2B transcripts is compared to that of 5-HT2C as well as proliferation and neurogenic markers. In developing brain and retina, 5-HT2B and 2C mRNAs are mainly expressed in proliferative regions. We suggest that these receptors may play a role in the larval secondary neurogenesis by mediating mitogenic effects of serotonin.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>12877990</pmid><doi>10.1016/S0169-328X(03)00173-6</doi><tpages>6</tpages></addata></record> |
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| subjects | 5-HT2B receptor Animals Biological and medical sciences Brain - embryology Brain - metabolism Bromodeoxyuridine - pharmacokinetics Cloning, Molecular Cyclin D1 - genetics Cyclin D1 - metabolism Development. Senescence. Regeneration. Transplantation Embryo, Nonmammalian Eye - embryology Eye - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental Genetic Markers In Situ Hybridization Larva - genetics Larva - metabolism Membrane Proteins - genetics Membrane Proteins - metabolism Molecular Sequence Data Nervous system development Radiation-Sensitizing Agents - pharmacokinetics Receptor, Notch1 Receptor, Serotonin, 5-HT2A Receptor, Serotonin, 5-HT2B Receptors, Cell Surface Receptors, Serotonin - genetics Receptors, Serotonin - metabolism Retina Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - biosynthesis Secondary neurogenesis Serotonin receptors Transcription Factors Vertebrates: nervous system and sense organs Xenopus Xenopus - genetics Xenopus Proteins - metabolism |
| title | Expression of 5-HT2B and 5-HT2C receptor genes is associated with proliferative regions of Xenopus developing brain and eye |
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