Expression of 5-HT2B and 5-HT2C receptor genes is associated with proliferative regions of Xenopus developing brain and eye

Here we clone the Xenopus 5-HT2B receptor cDNA and describe its spatio-temporal mRNA expression within the developing larval brain and visual system. Expression of the 5-HT2B transcripts is compared to that of 5-HT2C as well as proliferation and neurogenic markers. In developing brain and retina, 5-...

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Veröffentlicht in:	Brain research. Molecular brain research. 2003-07, Vol.115 (2), p.196-201
Hauptverfasser:	De Lucchini, Stefania, Ori, Michela, Nardini, Martina, Marracci, Silvia, Nardi, Irma
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT2B receptor Animals Biological and medical sciences Brain - embryology Brain - metabolism Bromodeoxyuridine - pharmacokinetics Cloning, Molecular Cyclin D1 - genetics Cyclin D1 - metabolism Development. Senescence. Regeneration. Transplantation Embryo, Nonmammalian Eye - embryology Eye - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental Genetic Markers In Situ Hybridization Larva - genetics Larva - metabolism Membrane Proteins - genetics Membrane Proteins - metabolism Molecular Sequence Data Nervous system development Radiation-Sensitizing Agents - pharmacokinetics Receptor, Notch1 Receptor, Serotonin, 5-HT2A Receptor, Serotonin, 5-HT2B Receptors, Cell Surface Receptors, Serotonin - genetics Receptors, Serotonin - metabolism Retina Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - biosynthesis Secondary neurogenesis Serotonin receptors Transcription Factors Vertebrates: nervous system and sense organs Xenopus Xenopus - genetics Xenopus Proteins - metabolism
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Zusammenfassung:	Here we clone the Xenopus 5-HT2B receptor cDNA and describe its spatio-temporal mRNA expression within the developing larval brain and visual system. Expression of the 5-HT2B transcripts is compared to that of 5-HT2C as well as proliferation and neurogenic markers. In developing brain and retina, 5-HT2B and 2C mRNAs are mainly expressed in proliferative regions. We suggest that these receptors may play a role in the larval secondary neurogenesis by mediating mitogenic effects of serotonin.
ISSN:	0169-328X 1872-6941
DOI:	10.1016/S0169-328X(03)00173-6