Effect of ipratropium bromide in bronchial asthma

The effect of inhalation of ipratropium bromide was evaluated in 20 patients with bronchial asthma. It was observed that there was no significant improvement in the forced vital capacity and the forced expired volume in one second, while there was significant improvement in the peak expiratory flow...

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Veröffentlicht in:	Journal of postgraduate medicine (Bombay) 1992-07, Vol.38 (3), p.124-126
Hauptverfasser:	Taskar, V, Mirchandani, L, Mahashur, A A, Sharma, R R, Kolhatkar, V P
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Adolescent Adult Aerosols Asthma - drug therapy Asthma - physiopathology Drug Administration Schedule Female Forced Expiratory Volume - drug effects Humans Ipratropium - administration & dosage Ipratropium - therapeutic use Male Peak Expiratory Flow Rate - drug effects Time Factors Vital Capacity - drug effects
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Zusammenfassung:	The effect of inhalation of ipratropium bromide was evaluated in 20 patients with bronchial asthma. It was observed that there was no significant improvement in the forced vital capacity and the forced expired volume in one second, while there was significant improvement in the peak expiratory flow rate (PEFR) measured at 9 pm, after inhalation of 2 puffs of ipratropium bromide aerosol (0.02mg/puff) three to four times a day for 2 weeks. Since PEFR is a measure of large airway function and cholinergic mechanisms are primarily involved for airflow obstruction at large airways, improvement in PEFR by ipratropium bromide highlights its role as a useful bronchodilator in patients in whom vagal reflexes are responsible for the provocation of bronchoconstriction.
ISSN:	0022-3859