Herpes simplex encephalitis relapses in children: Differentiation of two neurologic entities

Relapses of herpes simplex encephalitis (HSE) occurring after the completion of antiviral treatment have been reported repeatedly in children. The authors report data on six children who had at least one relapse of HSE. Two different mechanisms may account for these relapses, including viral replica...

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Veröffentlicht in:	Neurology 2003-07, Vol.61 (2), p.241-243
Hauptverfasser:	DE TIEGE, X, ROZENBERG, F, DES PORTES, V, LOBUT, J. B, LEBON, P, PONSOT, G, HERON, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyclovir - administration & dosage Acyclovir - therapeutic use Adolescent Antiviral Agents - administration & dosage Antiviral Agents - therapeutic use Basal Ganglia Diseases - etiology Biological and medical sciences Child Child, Preschool Encephalitis, Herpes Simplex - classification Encephalitis, Herpes Simplex - complications Encephalitis, Herpes Simplex - drug therapy Female Follow-Up Studies Human viral diseases Humans Infant Infectious diseases Male Medical sciences Recurrence Retrospective Studies Viral diseases Viral diseases of the nervous system
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Zusammenfassung:	Relapses of herpes simplex encephalitis (HSE) occurring after the completion of antiviral treatment have been reported repeatedly in children. The authors report data on six children who had at least one relapse of HSE. Two different mechanisms may account for these relapses, including viral replication or an immuno-inflammatory process, with different therapeutic attitudes. Relapses with viral replication may reveal host susceptibility to herpes simplex virus infection.
ISSN:	0028-3878 1526-632X
DOI:	10.1212/01.WNL.0000073985.71759.7C