Calcium ion homeostasis in smooth muscle

Ca 2+ plays an important role in the regulation of smooth-muscle contraction. In this review, we will focus on the various Ca 2+-transport processes that contribute to the cytosolic Ca 2+ concentration. Mainly the functional aspects will be covered. The smooth-muscle inositol 1,4,5-trisphosphate rec...

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Veröffentlicht in:	Pharmacology & therapeutics (Oxford) 1992-01, Vol.56 (2), p.191-231
Hauptverfasser:	Missiaen, Ludwig, De Smedt, Humbert, Droogmans, Guy, Himpens, Bernard, Casteels, Rik
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biological Transport Calcium - metabolism Cell Membrane - metabolism Cell Nucleus - metabolism Cytosol - metabolism Fundamental and applied biological sciences. Psychology Homeostasis Humans Muscle, Smooth - metabolism Striated muscle. Tendons Vertebrates: osteoarticular system, musculoskeletal system
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Beschreibung
Zusammenfassung:	Ca 2+ plays an important role in the regulation of smooth-muscle contraction. In this review, we will focus on the various Ca 2+-transport processes that contribute to the cytosolic Ca 2+ concentration. Mainly the functional aspects will be covered. The smooth-muscle inositol 1,4,5-trisphosphate receptor and ryanodine receptor will be extensively discussed. Smooth-muscle contraction also depends on extracellular Ca 2+ and both voltage- and Ca 2+-release-activated plasma-membrane Ca 2+ channels will be reviewed. We will finally discuss some functional properties of the Ca 2+ pumps that remove Ca 2+ from the cytoplasm and of the Ca 2+ regulation of the nucleus.
ISSN:	0163-7258 1879-016X
DOI:	10.1016/0163-7258(92)90017-T