Effect of calcium on mitochondria from human term placenta

We describe here the effects of free Ca 2+ on several functions of mitochondria from human term placenta. In thepresence of 0.1 μM free Ca 2+, an inhibitory effect on both ADP-induced respiration and succinate-DCPIP reductase activity was observed. At the same Ca 2+ concentration, ATPase activity as...

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Veröffentlicht in:	Placenta (Eastbourne) 1992-11, Vol.13 (6), p.535-544
Hauptverfasser:	Garduño, J.P., Espinosa-García, M.T., Pardo, J.P., Martinez, F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - metabolism Biological and medical sciences Calcium - pharmacology Electron Transport - drug effects Embryology: invertebrates and vertebrates. Teratology Female Fetal membranes Fundamental and applied biological sciences. Psychology General aspects. Development. Fetal membranes Humans Mitochondria - drug effects Mitochondrial ADP, ATP Translocases - metabolism Oxygen Consumption - drug effects Placenta - drug effects Placenta - ultrastructure Pregnancy Pregnancy Trimester, Third Progesterone - biosynthesis
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Zusammenfassung:	We describe here the effects of free Ca 2+ on several functions of mitochondria from human term placenta. In thepresence of 0.1 μM free Ca 2+, an inhibitory effect on both ADP-induced respiration and succinate-DCPIP reductase activity was observed. At the same Ca 2+ concentration, ATPase activity as well as various segments of the respiratory chain were stimulated. However, a higher free Ca 2+ concentration (0.3 μM) was needed to stimulate progesterone synthesis. Our results suggest that Ca 2+plays an important role in the metabolic functions of mitochondria from human term placenta.
ISSN:	0143-4004 1532-3102
DOI:	10.1016/0143-4004(92)90018-O