The relationship between reduced glutathione level and glutathione S-transferase activity in sheep erythrocytes

The relationship between reduced glutathione level and glutathione S-transferase activity in sheep erythrocytes

The relationship between reduced glutathione (GSH) level and glutathione S-transferase (GST) activity in erythrocytes was examined, using sheep erythrocytes, which have varying GSH concentrations, and dog erythrocytes with an inherited high concentration of GSH. There was a positive correlation (r =...

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Veröffentlicht in:The Japanese journal of veterinary research 1992-09, Vol.40 (2-3), p.99-104
Hauptverfasser: Goto, I. (Hokkaido Univ., Sapporo (Japan). Faculty of Veterinary Medicine), Agar, N.S, Maede, Y
Format: Artikel
Sprache:eng
Schlagworte:
ACTIVIDAD ENZIMATICA
ACTIVITE ENZYMATIQUE
Animals
CHEMICAL COMPOSITION
CHIEN
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
DOGS
ENZYMIC ACTIVITY
ERITROCITOS
ERYTHROCYTE
ERYTHROCYTES
Erythrocytes - enzymology
Erythrocytes - metabolism
Glutathione - metabolism
Glutathione Transferase - metabolism
OVIN
OVINOS
PEPTIDE
PEPTIDES
PEPTIDOS
PERRO
SHEEP
Sheep - blood
TRANSFERASAS
TRANSFERASE
TRANSFERASES
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Zusammenfassung:The relationship between reduced glutathione (GSH) level and glutathione S-transferase (GST) activity in erythrocytes was examined, using sheep erythrocytes, which have varying GSH concentrations, and dog erythrocytes with an inherited high concentration of GSH. There was a positive correlation (r = 0.529, p < 0.001) between the GSH level and GST activity in sheep erythrocytes. In dog erythrocytes, the GST activity in high-GSH cells was significantly (p < 0.001) higher than that in normal-GSH cells. These results indicate that the activity of GST in erythrocytes is directly correlated with the intracellular GSH level.
ISSN:0047-1917