Borna disease virus in mice: host-specific differences in disease expression

We developed a mouse model of Borna disease to facilitate immunopathogenesis research by adaptation of Borna disease virus to mice through serial passage in mouse brain tissue. Borna disease virus replication, antibody production, inflammation, and Borna disease expression in several different strai...

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Veröffentlicht in:	Journal of Virology 1993-01, Vol.67 (1), p.548-552
Hauptverfasser:	Rubin, S.A. (The Johns Hopkins University School of Medicine, Baltimore, MD), Waltrip, R.W. II, Bautista, J.R, Carbone, K.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Viral - blood Biological and medical sciences Borna Disease - microbiology Borna Disease - pathology Borna disease virus Borna disease virus - growth & development Brain - microbiology COMPORTAMIENTO ANORMAL COMPORTEMENT ANORMAL DIFERENCIAS BIOLOGICAS DIFFERENCE BIOLOGIQUE Disease Models, Animal ENCEFALITIS ENCEPHALITE Encephalitis - pathology ENFERMEDADES INMUNOLOGICAS EXPERIMENTACION IN VIVO Experimental viral diseases and models EXPERIMENTATION IN VIVO Genetic Variation INFECCION INFECTION Infectious diseases INFLAMACION INFLAMMATION MALADIE IMMUNOLOGIQUE Medical sciences Mice Mice, Inbred Strains MODELE MODELOS Motor Activity RATON REPONSE IMMUNITAIRE RESPUESTA INMUNOLOGICA Serial Passage SOURIS Viral diseases VIRUS DE LOS ANIMALES VIRUS DES ANIMAUX
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Beschreibung
Zusammenfassung:	We developed a mouse model of Borna disease to facilitate immunopathogenesis research by adaptation of Borna disease virus to mice through serial passage in mouse brain tissue. Borna disease virus replication, antibody production, inflammation, and Borna disease expression in several different strains of mice were examined
ISSN:	0022-538X 1098-5514
DOI:	10.1128/jvi.67.1.548-552.1993