Molecular pathogenesis of carcinoma of the esophagus

Carcinoma of the esophagus is present in two distinct morphological cell types: squamous or pavimentous cell carcinoma and adenocarcinoma. In this article, the main genetic alterations found in both types of carcinomas and their implications are described. The sequence of these alterations is relate...

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Veröffentlicht in:	Medicina (Buenos Aires) 2003, Vol.63 (3), p.237-248
Hauptverfasser:	Giménez, Alejandra M, Copelli, Silvia B, Speroni, Alfredo H, Meiss, Roberto P
Format:	Artikel
Sprache:	spa
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - pathology Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Esophageal Neoplasms - genetics Esophageal Neoplasms - pathology Genes, Tumor Suppressor - physiology Humans
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Beschreibung
Zusammenfassung:	Carcinoma of the esophagus is present in two distinct morphological cell types: squamous or pavimentous cell carcinoma and adenocarcinoma. In this article, the main genetic alterations found in both types of carcinomas and their implications are described. The sequence of these alterations is related to histogenesis, making it possible to understand tumor progression from normal epithelium to invasive carcinoma. A comparison is attempted between the molecular development of esophagus carcinomas and that of colorectal carcinoma.
ISSN:	0025-7680