Hippuristerones E-I, new polyoxygenated steroids from the gorgonian coral Isis hippuris

Five novel (22R,23S,24S)-steroids, hippuristerones E-I (1-5), have been isolated from the gorgonian coral Isis hippuris. The structures of steroids 1-5 were deduced by extensive 1D and 2D NMR studies ((1)H, (13)C, (1)H-(1)H COSY, HMQC, HMBC, and NOESY experiments). The structure of 1 was further sup...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2003-07, Vol.66 (7), p.917-921
Hauptverfasser:	Sheu, J.H, Huang, L.F, Chen, S.P, Yang, Y.L, Sung, P.J, Wang, G.H, Su, J.H, Chao, C.H, Hu, W.P, Wang, J.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Anthozoa - chemistry biochemical pathways Biological and medical sciences biosynthesis carbon chemical structure corals Fundamental and applied biological sciences. Psychology hippuristerones Isis hippuris methine methylene Molecular Conformation Molecular Structure Nuclear Magnetic Resonance, Biomolecular Other biological molecules Oxygen - chemistry protons spectral analysis stereochemistry steroids Steroids - chemistry Steroids - isolation & purification Taiwan Terpenes, steroids. Hormones
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Zusammenfassung:	Five novel (22R,23S,24S)-steroids, hippuristerones E-I (1-5), have been isolated from the gorgonian coral Isis hippuris. The structures of steroids 1-5 were deduced by extensive 1D and 2D NMR studies ((1)H, (13)C, (1)H-(1)H COSY, HMQC, HMBC, and NOESY experiments). The structure of 1 was further supported by molecular mechanics calculations.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np020602r