Kimura's disease and angiolymphoid hyperplasia with eosinophilia: Clinical and histopathologic differences

Background: There has been considerable controversy about the relation between Kimura's disease and angiolymphoid hyperplasia with eosinophilia (ALHE). Objective: We describe the clinical and histopathologic differences between the two diseases. Methods: We reviewed clinical findings and histopathologic changes in two cases of Kimura's disease and three cases of ALHE. Results: Kimura's disease shows typical lymphoid follicles. It is associated with lymphade-nopathy and is always accompanied by peripheral eosinophilia. ALHE shows typical changes in endothelial cells. It is characterized by superficial papules or nodules with no lymphade-nopathy and is less frequently accompanied by peripheral eosinophilia. Conclusion: Kimura's disease and ALHE are separate entities.