Age-related differences in the des IGF-I-mediated activation of Akt-1 and p70 S6K in mouse skeletal muscle

The ability of des IGF-I to activate Akt-1 and p70 S6K in skeletal muscle with or without acute endurance exercise was examined in young and old mice. Mice were sacrificed 12 h after a moderate intensity treadmill run following an interperitoneal injection of des-IGF-I or saline. Blood and skeletal...

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Veröffentlicht in:	Mechanisms of ageing and development 2003-07, Vol.124 (7), p.771-778
Hauptverfasser:	Li, Minghua, Li, Chunmei, Parkhouse, Wade S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - metabolism Akt-1 Animals Biological and medical sciences Blood Glucose - metabolism des IGF-I Exercise Female Fundamental and applied biological sciences. Psychology Insulin-Like Growth Factor I - metabolism Mice Mice, Inbred C57BL Muscle, Skeletal - metabolism p70 S6K Phosphorylation Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins Proto-Oncogene Proteins c-akt Receptor, IGF Type 1 - metabolism Ribosomal Protein S6 Kinases, 70-kDa - metabolism Skeletal muscle Striated muscle. Tendons Vertebrates: osteoarticular system, musculoskeletal system
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Zusammenfassung:	The ability of des IGF-I to activate Akt-1 and p70 S6K in skeletal muscle with or without acute endurance exercise was examined in young and old mice. Mice were sacrificed 12 h after a moderate intensity treadmill run following an interperitoneal injection of des-IGF-I or saline. Blood and skeletal muscle were collected and IGF-I receptor, Akt-1 and p70 S6K protein contents and their phosphorylation status were determined. Injection of des IGF-I similarly decreased plasma glucose concentration in both young ( P
ISSN:	0047-6374 1872-6216
DOI:	10.1016/S0047-6374(03)00124-6