Genetic polymorphisms of the interleukin-1 gene and early marginal bone loss around endosseous dental implants

: Dental implant surgery commonly proceeds in two stages. It is generally accepted that bone loss around implants does not occur at stage‐II surgery because implants do not receive mechanical loading. However, early marginal bone loss around implants occasionally does occur during the healing period. Genetic polymorphisms in the interleukin‐1 (IL‐1) gene have been reported to be important for bone homeostasis and susceptibility to bone disease. We therefore investigated whether the idiopathic early marginal bone loss around implants is related to polymorphisms in the IL‐1 gene. We performed a case‐control study. Patients demonstrating marginal bone loss around implants at stage‐II surgery were designated as the ‘marginal bone loss (+)’ group and those without bone loss as the ‘marginal bone loss (–)’ group. Polymorphisms of the IL‐1α and IL‐1β genes (IL‐1A−889, IL‐1B−511 and IL‐1B+3954) were detected by restriction fragment length polymorphism using NcoI, AvaI and TaqI after polymerase chain reactions. A total of 251 implants were placed in 39 patients. Marginal bone loss was observed in 36 implants. The patients with IL‐1B−511 2/2 genotype exhibited a significantly higher occurrence of marginal bone loss than those with IL‐1B−511 1/1 or 1/2 genotypes (OR=5.63; 95% CI=1.20–26.42; P=0.033). Multiple logistic regression analyses showed a markedly increased odds ratio (OR=10.86; 95% CI=1.64–71.90) in IL‐1B−511 2/2 genotype carriers, while ORs of the other risk factors for bone loss, such as age, smoking status, post‐menopausal women and bone quality, remained between 0.44 and 6.20. There was no significant difference in the distributions of the IL‐1B+3954 and IL‐1 A−889 genotypes between cases and controls. These data suggest that the IL‐1B−511 2/2 genotype has a significant association with the incidence of early marginal bone loss around endosseous implants. Résumé La chirurgie implantaire dentaire peut s'effectuer en deux étapes. Généralement, la perte osseuse autour des implants ne se produit pas lors de la deuxième chirurgie parce que les implants ne reçoivent pas de charge mécanique. Cependant, la perte osseuse marginale précoce autour des implants peut quelquefois survenir durant la période de guérison. Les polymorphismes génétiques du gène de l'interleukine‐1 (IL‐1) ont montré leur importance vis‐à‐vis de l'homéostase osseuse et de la prédisposition à la maladie osseuse. Une étude cas‐contrôle des polymorphismes du gène IL‐1 sur la perte osseuse margi