Evaluation of Treatment and Prophylaxis with Nitrofurans and Comparison with Alternative Antimicrobial Agents in Experimental Salmonella enterica Serovar enteritidis Infection in Chicks

The ability of the nitrofuran antimicrobial agents furazolidone and furaltadone to prevent, reduce or eliminate Salmonella enterica serovar enteritidis PT4 infection in artificially challenged day-old chicks was evaluated. Treating the birds with the nitrofurans failed to eliminate established infec...

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Veröffentlicht in:	Veterinary research communications 2003-05, Vol.27 (4), p.257-273
Hauptverfasser:	Chadfield, M.S, Hinton, M.H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use birds cecum Cecum - microbiology Chickens - microbiology chicks chloramphenicol disease control Drug Administration Schedule Drug Resistance, Bacterial drug therapy furaltadone furazolidone liver Nitrofurans - administration & dosage Nitrofurans - pharmacology Nitrofurans - therapeutic use Poultry Diseases - drug therapy Poultry Diseases - microbiology Salmonella enteritidis Salmonella enteritidis - drug effects Salmonella enteritidis - growth & development Salmonella enteritidis - physiology Salmonella Infections, Animal - drug therapy Salmonella Infections, Animal - microbiology spleen tetracycline trimethoprim
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Zusammenfassung:	The ability of the nitrofuran antimicrobial agents furazolidone and furaltadone to prevent, reduce or eliminate Salmonella enterica serovar enteritidis PT4 infection in artificially challenged day-old chicks was evaluated. Treating the birds with the nitrofurans failed to eliminate established infections with either furazolidone-resistant (FzR) or furazolidone-sensitive (FzS) strains. Simultaneous administration of the nitrofurans to day-old chicks challenged with FzS failed to prevent infection but reduced colonization significantly (p
ISSN:	0165-7380 1573-7446
DOI:	10.1023/A:1024039506986