Hypereosinophilia with abnormal T cells, trisomy 7 and elevated TARC serum level

INSERM U547, Institut Pasteur, 1 rue du Professeur Calmette, BP 245, 59019 LILLE Cedex, FRANCE. asroumier@yahoo.fr The idiopathic hypereosinophilic syndrome (HES) is a rare heterogeneous disorder, characterized by persistent blood eosinophilia with possible organ involvement. We describe here the case of a 20-year-old atopic male presenting chronic hypereosinophilia and eczema since childhood. Biological findings included hypereosinophilia (9.5 x 10(9)/L), hyperlymphocytosis (10.9 x 10(9)/L), polyclonal hypergammaglobulinemia and elevated IgE serum level. Flow cytometric analysis of blood lymphoid cells showed a population of CD2+CD3-CD4+TCRab-TCRgd- lymphocytes. These cells displayed a Th0/Th2 cytokine profile, and a clonal TCR rearrangement pattern. A high serum TARC level was observed. Karyotype studies on blood stimulated culture or lymph nodes revealed a cellular hyperdiploid clone 47, XY, +7. To our knowledge, this chromosomal aberration has never been reported in such case.