Inhibition of proliferation of tumour cell cultures by biologically active substances isolated from the tissues of Fasciola hepatica and Fasciola hepatica-infected rat liver

Biologically active substances (BAS) were isolated from the tissues of Fasciola hepatica and from F. hepatica-infected rat liver by ethanol precipitation from aqueous tissue homogenates. A marked inhibiting effect of the newly isolated BAS on hepatoma MC29 cell culture proliferation and a slight inh...

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Veröffentlicht in:	Folia parasitologica 1992-01, Vol.39 (4), p.387-390
Hauptverfasser:	Tsocheva, N. (Bulgarian Academy of Sciences, Sofia (Bulgaria). Inst. of Parasitology), Toshkova, R, Filchev, A
Format:	Artikel
Sprache:	eng
Schlagworte:	ADN Animals Cell Division Chickens Cricetinae CULTIVO DE CELULAS CULTURE DE CELLULE DNA, Neoplasm - biosynthesis FASCIOLA HEPATICA Fasciola hepatica - physiology Fascioliasis - metabolism FOIE Growth Inhibitors - isolation & purification Growth Inhibitors - physiology HIGADO INFESTACION INFESTATION INHIBICION INHIBITION Liver - metabolism NEOPLASMAS NEOPLASME RAT RATA Rats Rats, Wistar THYMIDINE TIMIDINA Tumor Cells, Cultured - metabolism Tumor Cells, Cultured - pathology
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Zusammenfassung:	Biologically active substances (BAS) were isolated from the tissues of Fasciola hepatica and from F. hepatica-infected rat liver by ethanol precipitation from aqueous tissue homogenates. A marked inhibiting effect of the newly isolated BAS on hepatoma MC29 cell culture proliferation and a slight inhibiting effect of the newly isolated BAS on myeloma cell culture proliferation was found. The strongest inhibiting effect was by BAS isolated from the tissues of F. hepatica. The inhibiting effect of the BAS isolated from F hepatica-infected liver was stronger than the effect of the BAS isolated from normal liver tissue.
ISSN:	0015-5683 1803-6465