Tethered Neuraminidase Inhibitors That Bind an Influenza Virus: A First Step Towards a Diagnostic Method for Influenza

Catching flu: The influenza virus neuraminidase inhibitor zanamivir (red) is functionalized at the 7‐position to give derivatives that retain a high affinity for the enzyme. When conjugated to biotin (green) or onto microspheres, such derivatives can be used to capture or aggregate influenza virus p...

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Veröffentlicht in:	Angewandte Chemie International Edition 2003-07, Vol.42 (27), p.3118-3121
Hauptverfasser:	McKimm-Breschkin, Jennifer L., Colman, Peter M., Jin, Betty, Krippner, Guy Y., McDonald, Mandy, Reece, Phillip A., Tucker, Simon P., Waddington, Lynne, Watson, Keith G., Wu, Wen-Yang
Format:	Artikel
Sprache:	eng
Schlagworte:	antiviral agents Biotin Enzyme-Linked Immunosorbent Assay glycoconjugates hydrolases influenza viruses Molecular Structure N-Acetylneuraminic Acid - chemistry N-Acetylneuraminic Acid - metabolism Neuraminidase - antagonists & inhibitors Orthomyxoviridae - drug effects Orthomyxoviridae - enzymology sialic acids
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Beschreibung
Zusammenfassung:	Catching flu: The influenza virus neuraminidase inhibitor zanamivir (red) is functionalized at the 7‐position to give derivatives that retain a high affinity for the enzyme. When conjugated to biotin (green) or onto microspheres, such derivatives can be used to capture or aggregate influenza virus particles.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200250402