Progress in liquid chromatography–mass spectrometry instrumentation and its impact on high-throughput screening

In the past 10 years, liquid chromatography–mass spectrometry (LC–MS) has rapidly matured to become a very powerful and useful analytical tool that is widely applied in many areas of chemistry, pharmaceutical sciences and biochemistry. In this paper, recent instrumental developments in LC–MS-related...

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Veröffentlicht in:	Journal of Chromatography A 2003-06, Vol.1000 (1), p.413-436
1. Verfasser:	Niessen, W.M.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Chemistry Chromatographic methods and physical methods associated with chromatography Chromatography, Liquid - instrumentation Exact sciences and technology Mass Spectrometry - instrumentation Other chromatographic methods
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description	In the past 10 years, liquid chromatography–mass spectrometry (LC–MS) has rapidly matured to become a very powerful and useful analytical tool that is widely applied in many areas of chemistry, pharmaceutical sciences and biochemistry. In this paper, recent instrumental developments in LC–MS-related interfacing, ionization and mass analysis are reviewed from the perspective of the application of LC–MS in high-throughput screening of combinatorial libraries and the related high-throughput quantitative bioanalysis in early drug-discovery studies, such as early adsorption, distribution, metabolism and excretion studies.
doi_str_mv	10.1016/S0021-9673(03)00506-5
format	Article
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subjects	Analytical chemistry Chemistry Chromatographic methods and physical methods associated with chromatography Chromatography, Liquid - instrumentation Exact sciences and technology Mass Spectrometry - instrumentation Other chromatographic methods
title	Progress in liquid chromatography–mass spectrometry instrumentation and its impact on high-throughput screening
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