Progress in liquid chromatography–mass spectrometry instrumentation and its impact on high-throughput screening
In the past 10 years, liquid chromatography–mass spectrometry (LC–MS) has rapidly matured to become a very powerful and useful analytical tool that is widely applied in many areas of chemistry, pharmaceutical sciences and biochemistry. In this paper, recent instrumental developments in LC–MS-related...
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Veröffentlicht in: | Journal of Chromatography A 2003-06, Vol.1000 (1), p.413-436 |
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Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | In the past 10 years, liquid chromatography–mass spectrometry (LC–MS) has rapidly matured to become a very powerful and useful analytical tool that is widely applied in many areas of chemistry, pharmaceutical sciences and biochemistry. In this paper, recent instrumental developments in LC–MS-related interfacing, ionization and mass analysis are reviewed from the perspective of the application of LC–MS in high-throughput screening of combinatorial libraries and the related high-throughput quantitative bioanalysis in early drug-discovery studies, such as early adsorption, distribution, metabolism and excretion studies. |
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ISSN: | 0021-9673 |
DOI: | 10.1016/S0021-9673(03)00506-5 |