Reproducible model of post-infarction left ventricular dysfunction: haemodynamic characterization by conductance catheter

Objective: The understanding of pathophysiology and cellular mechanisms of chronic heart failure requires the creation of appropriate and accurately characterized animal models, thus enabling meaningful evaluation of evolving medical and surgical therapies. Methods: The left anterior descending and...

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Veröffentlicht in:	European journal of cardio-thoracic surgery 2003-07, Vol.24 (1), p.98-104
Hauptverfasser:	Hasnat, A.K., van der Velde, Enno T., Hon, Jimmy K.F., Yacoub, Magdi H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cardiac Catheterization Cardiology. Vascular system Coronary heart disease End-systolic pressure–volume relationship Heart Hemodynamics Left ventricle Medical sciences Models, Animal Myocardial Infarction - complications Myocardial Infarction - pathology Myocardium - pathology Pre-load recruitable stroke work Sheep Time Factors Ventricular dysfunction Ventricular Dysfunction, Left - diagnosis Ventricular Dysfunction, Left - etiology
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Zusammenfassung:	Objective: The understanding of pathophysiology and cellular mechanisms of chronic heart failure requires the creation of appropriate and accurately characterized animal models, thus enabling meaningful evaluation of evolving medical and surgical therapies. Methods: The left anterior descending and its diagonal branch were ligated in 12 sheep to induce left ventricular dysfunction. Results: Study of left ventricular pressure–volume loops 3 months post-operatively showed a significant deterioration of both systolic and diastolic indexes of left ventricular function. The left ventricular end-diastolic pressure increased from 3±1 to 7±1 mmHg (P
ISSN:	1010-7940 1873-734X
DOI:	10.1016/S1010-7940(03)00261-6