Antiviral Activity of N-Benzoylphenylisoserinates of Lactarius Sesquiterpenoid Alcohols in vitro

Abstract Cytotoxic, antiviral, antibacterial and antifungal properties of a new, originally synthesised group of compounds: the N-benzoylphenylisoserinates of sesquiterpenoid alcohols - derivatives of taxol and various sesquiterpenes of LACTARIUS origin were evaluated IN VITRO. Among 16 compounds te...

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Veröffentlicht in:	Planta medica 2003-06, Vol.69 (6), p.552-554
Hauptverfasser:	Krawczyk, Ewa, Łuczak, Mirosław, Kobus, Mirosław, Bańka, Dariusz, Daniewski, Włodzimierz
Format:	Artikel
Sprache:	eng
Schlagworte:	Agaricales Alcohols - pharmacology Antiviral Agents - pharmacology Biological and medical sciences General pharmacology Herpesvirus 1, Human - drug effects Humans Letter Medical sciences Microbial Sensitivity Tests Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Serine - analogs & derivatives Serine - pharmacology Sesquiterpenes - pharmacology
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Zusammenfassung:	Abstract Cytotoxic, antiviral, antibacterial and antifungal properties of a new, originally synthesised group of compounds: the N-benzoylphenylisoserinates of sesquiterpenoid alcohols - derivatives of taxol and various sesquiterpenes of LACTARIUS origin were evaluated IN VITRO. Among 16 compounds tested, 6 decreased HSV-1 titres. Selectivity indices ranged from 13.9 to 31.7. No activity against RNA viruses (parainfluenza 3, Coxsackie B3, vesicular stomatitis virus, and encephalomyocarditis virus), bacteria: ESCHERICHIA COLI, PROTEUS MIRABILIS, STAPHYLOCOCCUS AUREUS, ENTEROCOCCUS FAECIUM and BACTEROIDES FRAGILIS and fungal strain of CANDIDA ALBICANS was detected.
ISSN:	0032-0943 1439-0221
DOI:	10.1055/s-2003-40649