Parkinson's Disease and Related α-Synucleinopathies Are Brain Amyloidoses

Parkinson's Disease and Related α-Synucleinopathies Are Brain Amyloidoses

: A paradigm shift in understanding Parkinson's disease (PD) and related disorders is emerging from studies showing that alpha‐synuclein (AS) gene mutations cause familial PD; AS is abnormally nitrated, phosphorylated, and ubiquitinated; AS forms neuronal and glial inclusions; AS fibrillizes in...

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Veröffentlicht in:Annals of the New York Academy of Sciences 2003-06, Vol.991 (1), p.107-110
Hauptverfasser: TROJANOWSKI, JOHN Q., LEE, VIRGINIA M-Y.
Format: Artikel
Sprache:eng
Schlagworte:
alpha-Synuclein
Amyloidosis - physiopathology
Animals
Brain - abnormalities
Brain - metabolism
Humans
Inclusion Bodies
Nerve Tissue Proteins - genetics
Nerve Tissue Proteins - metabolism
neurodegenerative brain amyloidoses
Parkinson's disease
Parkinsonian Disorders - etiology
Parkinsonian Disorders - genetics
Parkinsonian Disorders - metabolism
synucleinopathies
Synucleins
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Beschreibung
Zusammenfassung:: A paradigm shift in understanding Parkinson's disease (PD) and related disorders is emerging from studies showing that alpha‐synuclein (AS) gene mutations cause familial PD; AS is abnormally nitrated, phosphorylated, and ubiquitinated; AS forms neuronal and glial inclusions; AS fibrillizes in vitro; and AS transgenic animals develop neurodegeneration with AS amyloid inclusions. Thus, PD and related synucleinopathies are brain amyloidoses that may share similar mechanisms and targets for drug discovery.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2003.tb07468.x