PNEUMOCANDINS FROM Zalerion arboricola: I. DISCOVERY AND ISOLATION

HPLC bioautography of the directed biosynthesis of Zalerion arboricola led to the discovery of pneumocandin B0 (L-688, 786), a new antifungal and anti-Pneumocystis carinii lipopeptide. Isolation techniques were developed to separate this component from pneumocandin A0 (L-671, 329) in fermentations o...

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Veröffentlicht in:	Journal of antibiotics 1992/12/25, Vol.45(12), pp.1853-1866
Hauptverfasser:	SCHWARTZ, ROBERT E., SESIN, DAVID F., JOSHUA, HENRY, WILSON, KENNETH E., KEMPF, AUGUST J., GOKLEN, KENT A., KUEHNER, DANIEL, GAILLIOT, PATRICK, GLEASON, CAROLYN, WHITE, RAYMOND, INAMINE, EDWARD, BILLS, GERALD, SALMON, PETER, ZITANO, LAURETTA
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Applied microbiology Biological and medical sciences Biotransformation Candida albicans - drug effects Chromatography, Gel Chromatography, High Pressure Liquid Echinocandins Fundamental and applied biological sciences. Psychology Microbial Sensitivity Tests Microbiological Techniques Microbiology Mitosporic Fungi - chemistry Mitosporic Fungi - metabolism Peptides Peptides, Cyclic - chemistry Peptides, Cyclic - isolation & purification Peptides, Cyclic - pharmacology Pneumocystis - drug effects
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Beschreibung
Zusammenfassung:	HPLC bioautography of the directed biosynthesis of Zalerion arboricola led to the discovery of pneumocandin B0 (L-688, 786), a new antifungal and anti-Pneumocystis carinii lipopeptide. Isolation techniques were developed to separate this component from pneumocandin A0 (L-671, 329) in fermentations of a mutant of Zalerion arboricola. A number of related compounds were also isolated, which differ from pneurnocandins A0 and B0 in the hydroxylation patterns on the ornithine, homotyrosine, and proline.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.45.1853