Novel neurotensin analog blocks the initiation and expression of nicotine-induced locomotor sensitization

Neurotensin is a tridecapeptide that participates in regulation of dopaminergic pathways implicated in nicotine addiction. Previously, we showed that one of our brain-penetrating neurotensin analogs, NT69L, blocks nicotine-induced locomotor sensitization. The present work demonstrates that NT69L blo...

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Veröffentlicht in:	Brain research 2003-07, Vol.979 (1), p.245-248
Hauptverfasser:	Fredrickson, Paul, Boules, Mona, Yerbury, Sally, Richelson, Elliott
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain - drug effects Brain - metabolism Chromatography, High Pressure Liquid Dopamine - analysis Dopamine - metabolism Ganglionic Stimulants - pharmacology Male Medical sciences Motor Activity - drug effects Motor Activity - physiology Neurotensin Neurotensin - analogs & derivatives Neurotensin - pharmacology Nicotine Nicotine - pharmacology Norepinephrine - analysis Norepinephrine - metabolism NT69L Peptide Fragments - pharmacology Rats Rats, Sprague-Dawley Sensitization Serotonin - analysis Serotonin - metabolism Time Factors Tobacco, tobacco smoking Toxicology
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Beschreibung
Zusammenfassung:	Neurotensin is a tridecapeptide that participates in regulation of dopaminergic pathways implicated in nicotine addiction. Previously, we showed that one of our brain-penetrating neurotensin analogs, NT69L, blocks nicotine-induced locomotor sensitization. The present work demonstrates that NT69L blocks both the initiation and the expression of sensitization. In addition chronic NT69L administration blocked the acute effects of nicotine on norepinephrine and serotonin in prefrontal cortex.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/S0006-8993(03)02895-6