The effect of an antigenic stimulation on proliferative response in athymic mice

The proliferation activity of the main cellular categories of bone marrow after infusion of 3H-thymidine was studied in nu/nu and +/+ 1-month- and 3-month-old BALB/c mice in comparison with lymphoid cells in the spleen and mesenteric lymph nodes. The stem cell defect in nu/nu mouse bone marrow is co...

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Veröffentlicht in:Folia microbiologica 1992-01, Vol.37 (5), p.381-385
Hauptverfasser: Síma, P, Bilej, M, Kovárů, F, Vĕtvicka, V, Holub, M
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container_issue 5
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container_title Folia microbiologica
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creator Síma, P
Bilej, M
Kovárů, F
Vĕtvicka, V
Holub, M
description The proliferation activity of the main cellular categories of bone marrow after infusion of 3H-thymidine was studied in nu/nu and +/+ 1-month- and 3-month-old BALB/c mice in comparison with lymphoid cells in the spleen and mesenteric lymph nodes. The stem cell defect in nu/nu mouse bone marrow is compensated by an increased proliferation in myeloid series and in agranulocytes. The increase of proliferation activity among lymphoid cells in peripheral lymphoid organs was observed only in the 3-month-old mice with a delay in the nudes.
doi_str_mv 10.1007/BF02815667
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subjects Animals
Antigens - administration & dosage
Bone Marrow - immunology
Bone Marrow Cells
Colony-Forming Units Assay
Erythrocytes - immunology
Female
Hematopoietic Stem Cells - cytology
Hematopoietic Stem Cells - immunology
Lymphocyte Activation
Lymphoid Tissue - cytology
Lymphoid Tissue - immunology
Male
Mice
Mice, Inbred BALB C
Mice, Nude - immunology
Sheep
title The effect of an antigenic stimulation on proliferative response in athymic mice
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