The effect of an antigenic stimulation on proliferative response in athymic mice

The proliferation activity of the main cellular categories of bone marrow after infusion of 3H-thymidine was studied in nu/nu and +/+ 1-month- and 3-month-old BALB/c mice in comparison with lymphoid cells in the spleen and mesenteric lymph nodes. The stem cell defect in nu/nu mouse bone marrow is co...

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Veröffentlicht in:	Folia microbiologica 1992-01, Vol.37 (5), p.381-385
Hauptverfasser:	Síma, P, Bilej, M, Kovárů, F, Vĕtvicka, V, Holub, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens - administration & dosage Bone Marrow - immunology Bone Marrow Cells Colony-Forming Units Assay Erythrocytes - immunology Female Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - immunology Lymphocyte Activation Lymphoid Tissue - cytology Lymphoid Tissue - immunology Male Mice Mice, Inbred BALB C Mice, Nude - immunology Sheep
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Beschreibung
Zusammenfassung:	The proliferation activity of the main cellular categories of bone marrow after infusion of 3H-thymidine was studied in nu/nu and +/+ 1-month- and 3-month-old BALB/c mice in comparison with lymphoid cells in the spleen and mesenteric lymph nodes. The stem cell defect in nu/nu mouse bone marrow is compensated by an increased proliferation in myeloid series and in agranulocytes. The increase of proliferation activity among lymphoid cells in peripheral lymphoid organs was observed only in the 3-month-old mice with a delay in the nudes.
ISSN:	0015-5632 1874-9356
DOI:	10.1007/BF02815667