The IgA receptor complex: a two-for-one deal

IgA triggers immune responses by binding to Fc receptors on cells of the immune system. The structure of IgA1-Fc in a complex with two molecules of FcαRI provides clues that may explain the selectivity of IgA-mediated immune events.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature structural & molecular biology 2003-08, Vol.10 (8), p.585-587
Hauptverfasser:	Wurzburg, Beth A, Jardetzky, Theodore S
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological Microscopy Biomedical and Life Sciences Humans Immunoglobulin A - chemistry Immunoglobulin A - metabolism Life Sciences Macromolecular Substances Membrane Biology Models, Molecular news-and-views Protein Structure Receptors, Fc - chemistry Receptors, Fc - metabolism Receptors, IgE - chemistry Receptors, IgE - metabolism Receptors, IgG - chemistry Receptors, IgG - metabolism
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Beschreibung
Zusammenfassung:	IgA triggers immune responses by binding to Fc receptors on cells of the immune system. The structure of IgA1-Fc in a complex with two molecules of FcαRI provides clues that may explain the selectivity of IgA-mediated immune events.
ISSN:	1072-8368 1545-9993 2331-365X 1545-9985
DOI:	10.1038/nsb0803-585