Cajucarinolide and isocajucarinolide: anti-inflammatory diterpenes from Croton cajucara

Cajucarinolide and isocajucarinolide, two new clerodane diterpenes, have been isolated from the cortices of Croton cajucara (Euphorbiaceae). These compounds possess anti-inflammatory activity and inhibit bee venom phospholipase A(2) in vitro.

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Bibliographische Detailangaben
Veröffentlicht in:	Planta medica 1992-12, Vol.58 (6), p.549-551
Hauptverfasser:	Ichihara, Y. (Tokyo Coll. of Pharmacy (Japan). Dept. of Pharmacognosy), Takeya, K, Hitotsuyanagi, Y, Morita, H, Okuyama, S, Suganuma, M, Fujiki, H, Motidome, M, Itokawa, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anti-inflammation Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - isolation & purification Anti-Inflammatory Agents, Non-Steroidal - pharmacology ANTIINFLAMMATOIRE ANTINFLAMATORIOS Biological and medical sciences Cajucarinolide clerodane diterpene COMPOSICION QUIMICA COMPOSITION CHIMIQUE CROTON Croton cajucara Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology DITERPENOIDE DITERPENOS ESTRUCTURA QUIMICA Euphorbiaceae General pharmacology isocajucarinolide Medical sciences Mice Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phospholipase A inhibitor Phospholipases A - antagonists & inhibitors Phospholipases A2 PLANTAS MEDICINALES PLANTE MEDICINALE Plants - chemistry Spiro Compounds - chemistry Spiro Compounds - isolation & purification Spiro Compounds - pharmacology STRUCTURE CHIMIQUE teleocidin
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Beschreibung
Zusammenfassung:	Cajucarinolide and isocajucarinolide, two new clerodane diterpenes, have been isolated from the cortices of Croton cajucara (Euphorbiaceae). These compounds possess anti-inflammatory activity and inhibit bee venom phospholipase A(2) in vitro.
ISSN:	0032-0943 1439-0221
DOI:	10.1055/s-2006-961547