A Transient N−O-Linked Pauson−Khand Strategy for the Synthesis of the Deschloro Carbocyclic Core of the Palau'amines and Styloguanidines

A Transient N−O-Linked Pauson−Khand Strategy for the Synthesis of the Deschloro Carbocyclic Core of the Palau'amines and Styloguanidines

A stereocontrolled route to the deschloro cyclopentyl core of the palau'amines and styloguanidines has been developed. This strategy makes use of the intramolecular Pauson−Khand cyclization of an enyne with a “transient N−O tether” to construct a five-membered carbocycle in a diastereoselective...

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Veröffentlicht in:Organic letters 2003-06, Vol.5 (13), p.2203-2206
Hauptverfasser: Koenig, Stefan G, Miller, Stefan M, Leonard, Kristi A, Löwe, Ralf S, Chen, Betty C, Austin, David J
Format: Artikel
Sprache:eng
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Zusammenfassung:A stereocontrolled route to the deschloro cyclopentyl core of the palau'amines and styloguanidines has been developed. This strategy makes use of the intramolecular Pauson−Khand cyclization of an enyne with a “transient N−O tether” to construct a five-membered carbocycle in a diastereoselective fashion.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0344063